6-Vinylated guanosine as a novel cross-linking agent and its versatile synthesis from the 6-O-tosylate by Pd(0)-catalyzed cross-coupling

Fumi Nagatsugi, Kengo Uemura, Shouji Nakashima, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

6-Vinylated guanosine (1) was designed as a novel cross-linking agent, and synthesized by a new Pd(0)-catalyzed cross-coupling reaction using guanosine 6-O-tosylate and vinyltributylstannane. Its potential as a cross-linking agent was demonstrated by adduct formation with guanosine and cytidine at the 7-N and 4-N positions, respectively.

Original languageEnglish
Pages (from-to)421-424
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number3
DOIs
Publication statusPublished - 1995 Jan 16
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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