6-[18F]Fluorodopa metabolism in patients with hemiparkinsonism studied by positron emission tomography

Haruo Nagasawa, Hiroshi Saito, Kyuya Kogure, Jun Hatazawa, Masatoshi Itoh, Takehiko Fujiwara, Shoichi Watanuki, Shinya Seo, Ren Iwata, Tatsuo Ido

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A group of 10 healthy control subjects and 10 patients with hemiparkinsonism (HD) were studied by positron emission tomography (PET) using 6-[18F]fluorodopa (FDOPA). FDOPA metabolism in the caudate nucleus and the putamen was separately estimated by measuring target-to-background ratios (TBRs) using composite images added between 30 and 60 min after FDOPA injection and by TBR-versus-time slopes during PET study. TBRs in the caudate nucleus and the putamen were 1.81 ± 0.23 (mean ± SD) and 1.92 ± 0.28 in the 10 controls, respectively. In HD patients, on the dominantly affected hemisphere related to main clinical symptoms, TBRs were significantly decreased in the caudate nucleus (P < 0.01) and the putamen (P < 0.05) compared with those in the corresponding areas on the contralateral hemisphere, though those TBRs on both hemispheres were significantly decreased compared with the TBRs of normal subjects (P < 0.01). TBRs and TBR slopes in both the caudate nucleus and the putamen were correlated with disease severity according to Hoehn and Yahr. On the dominantly affected hemisphere, TBR and TBR slopes in the putamen were well correlated with individual clinical measures for bradykinesia and rigidity, and those in the caudate nucleus were also correlated with the severity of tremor. Our data suggest that in HD patients, PET study using FDOPA may provide unique and efficient information on the dysfunction of the dominantly affected caudate nucleus and the putamen which are correlated with disease severity and individual clinical symptoms.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalJournal of the neurological sciences
Volume115
Issue number2
DOIs
Publication statusPublished - 1993 Jan 1

Keywords

  • 6-[F]Fluorodopa
  • Hemiparkinsonism
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of '6-[<sup>18</sup>F]Fluorodopa metabolism in patients with hemiparkinsonism studied by positron emission tomography'. Together they form a unique fingerprint.

  • Cite this

    Nagasawa, H., Saito, H., Kogure, K., Hatazawa, J., Itoh, M., Fujiwara, T., Watanuki, S., Seo, S., Iwata, R., & Ido, T. (1993). 6-[18F]Fluorodopa metabolism in patients with hemiparkinsonism studied by positron emission tomography. Journal of the neurological sciences, 115(2), 136-143. https://doi.org/10.1016/0022-510X(93)90216-L