Abstract
Reduction of α-ketoesters bearing 5(N-methylbenzoylamino)-2,2,6,6-tetramethylheptan-3-ol as a chiral auxillary proceeds with high diastereoselectivity by using DIBAL as a reducing agent. The chiral auxiliary is recovered upon treatment with base, and α-hydroxy carboxylic acids are obtained in good al yields with high enantioselectivity.
Original language | English |
---|---|
Pages (from-to) | 1863-1866 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1996 Mar 11 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry