5(N-methylbenzoylamino)-2,2,6,6-tetramethylheptan-3-ol as a new class of recoverable chiral auxiliary

Yoshinori Yamamoto, Hirofumi Kin, Ichiro Suzuki, Naoki Asao

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Reduction of α-ketoesters bearing 5(N-methylbenzoylamino)-2,2,6,6-tetramethylheptan-3-ol as a chiral auxillary proceeds with high diastereoselectivity by using DIBAL as a reducing agent. The chiral auxiliary is recovered upon treatment with base, and α-hydroxy carboxylic acids are obtained in good al yields with high enantioselectivity.

    Original languageEnglish
    Pages (from-to)1863-1866
    Number of pages4
    JournalTetrahedron Letters
    Volume37
    Issue number11
    DOIs
    Publication statusPublished - 1996 Mar 11

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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