5-FU metabolism in cancer and orally-administrable 5-FU drugs

Koh Miura, Makoto Kinouchi, Kazuyuki Ishida, Wataru Fujibuchi, Takeshi Naitoh, Hitoshi Ogawa, Toshinori Ando, Nobuki Yazaki, Kazuhiro Watanabe, Sho Haneda, Chikashi Shibata, Iwao Sasaki

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

5-Fluorouracil (5-FU) is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

Original languageEnglish
Pages (from-to)1717-1730
Number of pages14
JournalCancers
Volume2
Issue number3
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • 5-FU metabolism
  • Cell death
  • Colon cancer
  • Oral 5-FU drugs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Miura, K., Kinouchi, M., Ishida, K., Fujibuchi, W., Naitoh, T., Ogawa, H., Ando, T., Yazaki, N., Watanabe, K., Haneda, S., Shibata, C., & Sasaki, I. (2010). 5-FU metabolism in cancer and orally-administrable 5-FU drugs. Cancers, 2(3), 1717-1730. https://doi.org/10.3390/cancers2031717