42. A Novel Point Mutation of the RET Proto-oncogene in Small Cell Lung Carcinoma Cell Lines

Hitoyasu Futami, Shin ichi Egawa, Ken Yamaguchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Point mutations of the RET proto-oncogene are associated with the development of inherited diseases including multiple endocrine neoplasia (MEN) type 2, familial medullary thyroid carcinoma (MTC), and Hirschsprung’s disease as well as a part of sporadic MTCs and pheochromocytomas. In the present study, we examined point mutations of the RET proto-oncogene in exons 10, 11 and 16 in small cell lung carcinoma (SCLC) cell lines. A novel point mutation from GCC to GAC at codon 664 in exon 11 was identified in 2 out of 6 SCLC cell lines; this alteration results in an amino acid substitution of aspartic acid for alanine. This point mutation was not detected in other types of cancer cell lines so far examined. Point mutations of the RET proto-oncogene reported previously in exons 10, 11 and 16 in above-mentioned diseases were not detected in the SCLC cell lines. These results suggest that this point mutation of the RET proto-oncogene is closely associated with a part of SCLC.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalProceedings of the Japan Academy, Series B
Volume70
Issue number10
DOIs
Publication statusPublished - 1994 Jan 1
Externally publishedYes

Keywords

  • Medullary thyroid carcinoma
  • Multiple endocrine neoplasia
  • Point mutation
  • RET
  • Small cell lung carcinoma

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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