4-Chloro-2-azaadamantane N-Oxyl (4-Cl-AZADO): A Readily Preparable Organocatalyst for NOx Co-catalyzed Aerobic Alcohol Oxidation

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Abstract

Concise synthesis and structure-activity relationships study of 4-substituted 2-azaadamantane N-oxyls reveals that 4-chloro-2-azaadamantane N-oxyl (4-Cl-AZADO) is an efficient organocatalyst toward the aerobic oxidation of alcohols in the presence of NOx as a co-catalyst. The organocatalyst was easily synthesized from 2-adamantanone in five steps, and it showed high activity compared with many previously reported nitroxyl radical catalysts.

Original languageEnglish
JournalAsian Journal of Organic Chemistry
DOIs
Publication statusAccepted/In press - 2023

Keywords

  • Alcohol
  • Organocatalysis
  • Oxidation
  • Radicals
  • Synthetic method

ASJC Scopus subject areas

  • Organic Chemistry

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