2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Yusuke Sato, Yu Toriyabe, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

Original languageEnglish
Pages (from-to)9983-9985
Number of pages3
JournalChemical Communications
Volume49
Issue number85
DOIs
Publication statusPublished - 2013 Oct

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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