(2+2) Cycloaddition reaction of alkyl enol ethers with acrylates by in situ generated silyl triflic imide catalyst

Kiyosei Takasu, Yuta Miyakawa, Masataka Ihara, Hidetoshi Tokuyama

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We describe here (2+2) cycloaddition reaction of alkyl enol ethers with acrylates catalyzed by triethylsilyl triflic imide (Et3SiNTf 2), which was in situ generated from triethylsilane and triflic imide. The reaction efficiently provides substituted cyclobutanes bearing alkoxy function in a stereoselective manner.

Original languageEnglish
Pages (from-to)1205-1206
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number8
DOIs
Publication statusPublished - 2008 Aug 1

Keywords

  • (2+2) cycloaddition
  • Cyclobutane
  • Silane
  • Triflic imide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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