2-Oxo-1,2-ethylenedioxy group as a linker for solution-, liquid-, and solid-phase syntheses to discover drug-like small molecules

Masato Oikawa, Yoshiyuki Takeda, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

2-Oxo-1,2-ethylenedioxy (2-OED) functionality has been prepared on a soluble MPEG polymer and solid (HM resin and Lanterns) supports as platforms for discovery of drug-like small molecules. The functionality is cleaved either by Yb(OTf)3 or TMSCHN2 in MeOH, or by various amines to release small molecules synthesized on the platform in good yield. Application of these platforms aiming for discovery of potent agonists for growth hormone secretagogue is reported by using the Ugi four-component coupling reaction.

Original languageEnglish
Pages (from-to)4667-4670
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number27
DOIs
Publication statusPublished - 2005 Jul 4

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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