2′-deoxy-4′-C-ethynyl-2-fluoroadenosine: A nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma

Hiroshi Ohrui, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroaki Mitsuya

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Working hypotheses to solve the critical problems of the existing highly active anti-retroviral therapy were proposed. The study based on the hypotheses proved the validity of the hypotheses and resulted in the development of 2′-deoxy-4′-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, with highly potent activity against all HIV-1, very favorable toxic profiles, and stability in plasma. The nucleoside will prevent or delay the emergence of drug-resistant HIV-1 variants and be an ideal therapeutic agent for both HIV-1 and HBV infections.

Original languageEnglish
Pages (from-to)1543-1546
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number10-12
DOIs
Publication statusPublished - 2007 Oct 1
Externally publishedYes

Keywords

  • 2,′3′- dideoxynucleoside
  • 2′-Deoxy-4′-C-ethynyl nucleoside
  • Drug resistant HIV
  • HAART
  • Nucleoside reverse transcriptase inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

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