2-Deoxy-2-[18F]fluoro-D-galactose: A nes probe for the evaluation of liver function by PET. II. A first clinical PET study of the liver in normal volunteers

H. Fukuda, K. Yamaguchi, T. Matsuzawa, M. Itoh, Y. Abe, T. Fujiwara, H. Miyazawa, H. Kawai, H. Matsui

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

2-deoxy2-[18F]fluoro-D-galacgtose (18FDGal) is a new probe for the evaluation of galactose metabolism in the liver. We firstly examined its clinical usefulness in 5 normal volunteers. After 2 mCi 18FDGal injection, serial PET scans were performed every 5 min. The radioactivity in the liver increased with time and reached a plateau at 30-40 min after injection. The liver uptake at 50 min was very high, 26.4 expressed by % dose/ml x 10-3, and high quality images were obtained. Radiation doses calculated by liver radioactivity based on the MIRD schema were repsectively 530 and 50 mrad/mCi for the liver and total body. The values were consistent with our previous calculation that were obtained on the basis of animal biodistribution.

Original languageEnglish
Pages (from-to)871-874
Number of pages4
JournalKakuigaku
Volume24
Issue number6
Publication statusPublished - 1987 Nov 9
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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