Abstract
New optically active 2-azanorbornane-based amino alcohol organocatalysts were designed and synthesized, and these catalysts were successfully employed in the asymmetric Michael reaction of β-keto esters with nitroolefins to obtain the corresponding chiral Michael adducts with both high chemical yields (up to 99 %) and high stereoselectivities (up to dr = 91:9, up to 91 % ee).
Original language | English |
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Pages (from-to) | 3882-3889 |
Number of pages | 8 |
Journal | European Journal of Organic Chemistry |
Volume | 2019 |
Issue number | 24 |
DOIs | |
Publication status | Published - 2019 Jun 30 |
Keywords
- 2-Azanorbornane
- Amino alcohols
- Asymmetric reaction
- Michael addition
- Organocatalyst
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry