2-aminopurine-modified abasic-site-containing duplex DNA for highly selective detection of theophylline

Minjie Li, Yusuke Sato, Seiichi Nishizawa, Takehiro Seino, Kodai Nakamura, Norio Teramae

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

2-Aminopurine-modified abasic-site-containing duplex [DNA 5́-TCTGC GTCCT PXT TAACG CACAC-3́/3́-AGACG CAGGA TCA ATTGC GTGTG-5́; P = 2-aminopurine, X = abasic site (Spacer-C3), C = receptor base] is capable of selectively binding to the bronchodilator theophylline with a dissociation constant of 10 μM (5 °C, pH 7.0, I = 0.11 M) and is applicable to monitoring serum theophylline concentrations.

Original languageEnglish
Pages (from-to)2448-2449
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number7
DOIs
Publication statusPublished - 2009 Feb 25

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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