18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism

Yasuhiro Nakamura; Fumitoshi Satoh; Ryo Morimoto; Masataka Kudo; Kei Takase; Celso E. Gomez-Sanchez; Seijiro Honma; Mitsunobu Okuyama; Kouwa Yamashita; William E. Rainey; Hironobu Sasano; Sadayoshi Ito

doi:10.1210/jc.2010-2785

18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism

Yasuhiro Nakamura, Fumitoshi Satoh, Ryo Morimoto, Masataka Kudo, Kei Takase, Celso E. Gomez-Sanchez, Seijiro Honma, Mitsunobu Okuyama, Kouwa Yamashita, William E. Rainey, Hironobu Sasano, Sadayoshi Ito

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined. Objectives: We measured 18-oxoF, aldosterone, and F in plasma from adrenal vein sampling (AVS) of patients with primary aldosteronism.Wecompared 18-oxoF levels and 18-oxoF/F ratios for their potential to differentiate APA from IHA. Design, Setting, and Subjects: This study measured 18-oxoF, F, and aldosterone in AVS obtained from patients with unilateral APA (14 cases) or bilateral IHA (seven cases, 14 samples total) using liquid chromatography-tandem mass spectrometry and RIA analyses. Results: The levels of 18-oxoF and the ratios of 18-oxoF/F, before and after ACTH stimulation, were significantly higher in blood-draining APA than in those from the contralateral adrenal glands and from adrenal glands with IHA. Conclusions: The 18-oxoF levels and ratios of 18-oxoF/F in AVS samples can be a clinically useful biomarker for differentiating APA from IHA and for determining the localization or lateralization of APA in patients with primary aldosteronism.

Original language	English
Pages (from-to)	E1272-E1278
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	96
Issue number	8
DOIs	https://doi.org/10.1210/jc.2010-2785
Publication status	Published - 2011 Aug

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Nakamura, Y., Satoh, F., Morimoto, R., Kudo, M., Takase, K., Gomez-Sanchez, C. E., Honma, S., Okuyama, M., Yamashita, K., Rainey, W. E., Sasano, H., & Ito, S. (2011). 18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. Journal of Clinical Endocrinology and Metabolism, 96(8), E1272-E1278. https://doi.org/10.1210/jc.2010-2785

18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. / Nakamura, Yasuhiro; Satoh, Fumitoshi ; Morimoto, Ryo; Kudo, Masataka; Takase, Kei; Gomez-Sanchez, Celso E.; Honma, Seijiro; Okuyama, Mitsunobu; Yamashita, Kouwa; Rainey, William E.; Sasano, Hironobu; Ito, Sadayoshi.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 8, 08.2011, p. E1272-E1278.

Research output: Contribution to journal › Article › peer-review

Nakamura, Y, Satoh, F , Morimoto, R, Kudo, M, Takase, K, Gomez-Sanchez, CE, Honma, S, Okuyama, M, Yamashita, K, Rainey, WE, Sasano, H & Ito, S 2011, '18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 8, pp. E1272-E1278. https://doi.org/10.1210/jc.2010-2785

Nakamura, Yasuhiro ; Satoh, Fumitoshi ; Morimoto, Ryo ; Kudo, Masataka ; Takase, Kei ; Gomez-Sanchez, Celso E. ; Honma, Seijiro ; Okuyama, Mitsunobu ; Yamashita, Kouwa ; Rainey, William E. ; Sasano, Hironobu ; Ito, Sadayoshi. / 18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 8. pp. E1272-E1278.

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abstract = "Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined. Objectives: We measured 18-oxoF, aldosterone, and F in plasma from adrenal vein sampling (AVS) of patients with primary aldosteronism.Wecompared 18-oxoF levels and 18-oxoF/F ratios for their potential to differentiate APA from IHA. Design, Setting, and Subjects: This study measured 18-oxoF, F, and aldosterone in AVS obtained from patients with unilateral APA (14 cases) or bilateral IHA (seven cases, 14 samples total) using liquid chromatography-tandem mass spectrometry and RIA analyses. Results: The levels of 18-oxoF and the ratios of 18-oxoF/F, before and after ACTH stimulation, were significantly higher in blood-draining APA than in those from the contralateral adrenal glands and from adrenal glands with IHA. Conclusions: The 18-oxoF levels and ratios of 18-oxoF/F in AVS samples can be a clinically useful biomarker for differentiating APA from IHA and for determining the localization or lateralization of APA in patients with primary aldosteronism.",

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AU - Takase, Kei

AU - Gomez-Sanchez, Celso E.

AU - Honma, Seijiro

AU - Okuyama, Mitsunobu

AU - Yamashita, Kouwa

AU - Rainey, William E.

AU - Sasano, Hironobu

AU - Ito, Sadayoshi

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N2 - Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined. Objectives: We measured 18-oxoF, aldosterone, and F in plasma from adrenal vein sampling (AVS) of patients with primary aldosteronism.Wecompared 18-oxoF levels and 18-oxoF/F ratios for their potential to differentiate APA from IHA. Design, Setting, and Subjects: This study measured 18-oxoF, F, and aldosterone in AVS obtained from patients with unilateral APA (14 cases) or bilateral IHA (seven cases, 14 samples total) using liquid chromatography-tandem mass spectrometry and RIA analyses. Results: The levels of 18-oxoF and the ratios of 18-oxoF/F, before and after ACTH stimulation, were significantly higher in blood-draining APA than in those from the contralateral adrenal glands and from adrenal glands with IHA. Conclusions: The 18-oxoF levels and ratios of 18-oxoF/F in AVS samples can be a clinically useful biomarker for differentiating APA from IHA and for determining the localization or lateralization of APA in patients with primary aldosteronism.

AB - Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2). The potential for this steroid as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA) has not been examined. Objectives: We measured 18-oxoF, aldosterone, and F in plasma from adrenal vein sampling (AVS) of patients with primary aldosteronism.Wecompared 18-oxoF levels and 18-oxoF/F ratios for their potential to differentiate APA from IHA. Design, Setting, and Subjects: This study measured 18-oxoF, F, and aldosterone in AVS obtained from patients with unilateral APA (14 cases) or bilateral IHA (seven cases, 14 samples total) using liquid chromatography-tandem mass spectrometry and RIA analyses. Results: The levels of 18-oxoF and the ratios of 18-oxoF/F, before and after ACTH stimulation, were significantly higher in blood-draining APA than in those from the contralateral adrenal glands and from adrenal glands with IHA. Conclusions: The 18-oxoF levels and ratios of 18-oxoF/F in AVS samples can be a clinically useful biomarker for differentiating APA from IHA and for determining the localization or lateralization of APA in patients with primary aldosteronism.

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18-Oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism

Abstract

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