17β-hydroxysteroid dehydrogenases in human breast cancer

Shuji Nagasaki, Yasuhiro Miki, Jun Ichi Akahira, Takashi Suzuki, Hironobu Sasano

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Citations (Scopus)

Abstract

Estrogen plays a pivotal role in development and progression of human breast carcinoma. Before menopause the main source of estrogen in women is circulating estrogen secreted from the ovary, but following menopause the source changes to the hormone that is converted from circulating adrenal androgens in peripheral tissues. Therefore, adrenal androgens have to be converted to estrogen to stimulate breast carcinoma cells. In these steps, several enzymes such as aromatase, steroid sulfatase, and 17β-hydroxysteroid dehydrogenases (17β-HSDs) are involved in the production of estrogens. The reaction related to 17β-HSDs activity is one of the last steps of estradiol biosynthesis, and 14 isozymes of 17β-HSD have been identified at this juncture. The balance of the relative expression levels of 17β-HSD isozymes in human breast carcinomas is thought to play a pivotal role in supply of estradiol to estrogen receptor positive carcinoma cells. Understanding the character of 17β-HSD isozymes in human breast carcinoma thus provides important information on the mechanisms of biosynthesis of estradiol in breast carcinoma and for development of a therapeutic agent targeted for inhibition of local estradiol synthesis in breast carcinoma cells. In the present review we summarize the roles played by 17β-HSDs in human breast carcinoma to obtain a better understanding of the properties of 17β-HSDs in human breast carcinoma.

Original languageEnglish
Title of host publicationSteroid Enzymes and Cancer
PublisherBlackwell Publishing Inc.
Pages25-32
Number of pages8
ISBN (Print)9781573317450
DOIs
Publication statusPublished - 2009 Feb

Publication series

NameAnnals of the New York Academy of Sciences
Volume1155
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • 17β-hydroxysteroid dehydrogenase (17β-HSD)
  • Breast cancer
  • Dehydroepiandrosterone (DHEA)
  • Estrogen
  • Intracrinology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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