Alzheimer's disease (AD) is characterized by the deposition of amyloid β-peptide (Aβ), derived from amyloid precursor protein (APP). Membrane states, such as lipid components or membrane fluidity, are important for enzymes related to APP processing in meeting their substrates efficiently. We analyzed the effects of triglycerides combined with polyunsaturated fatty acids (PUFAs) and/or caprylic acids on APP proteolysis. Our results showed that 1,3-capryloyl-2-arachidonoyl glycerol (8A8) moderately increased α-secretase activity (18%) in A172 cells. β-Secretase activity was not statistically significantly changed in HEK293 cells stably expressing BACE1. However, Aβ40 secretion decreased by 22%. Thus, we conclude that 8A8 is a useful lipid compound for activating α-secretase activity and suppressing Aβ40 secretion.
- Alzheimer's disease
- Amyloid precursor protein (APP)
- Arachidonic acid
- Medium chain fatty acid
ASJC Scopus subject areas