1-Phenyl-2-(1-pyrrolidinyl)-1-propanol as a chiral catalyst for the highly enantioselective addition of dialkylzincs to five-membered heterocyclic aldehydes

Itaru Sato, Takahiro Saito, Daisuke Omiya, Yoshiko Takizawa, Kenso Soai

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

(1S, 2R)- and (1R, 2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol catalyze the enantioselective addition of dialkylzincs to furaldehydes, thiophenecarbaldehydes, and 1-(p-tosyl)-2-pyrrolecarbaldehyde to afford the corresponding enantiomerically enriched sec-alcohols with up to 87% enantiomeric excess.

Original languageEnglish
Pages (from-to)2753-2758
Number of pages6
JournalHeterocycles
Volume51
Issue number11
DOIs
Publication statusPublished - 1999 Nov 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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