1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei

Qing Wen Shi, Yong Ming Zhao, Xiao Tang Si, Zuo Ping Li, Teiko Yamada, Hiromasa Kiyota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A new paclitaxel derivative and two new 2(3→20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7β,10β- diacetoxy-2α,5α,13α-trihydroxy-2(3→20)-abeo-taxa-4(20), 11-dien-9-one (2), and 2α,13α-diacetoxy-10α-hydroxy- 2(3→20)-abeo-taxa-4(20),6,11-triene-5,9-dione (3) on the basis of spectroscopic data analysis. Taxane 1 is the first example of a paclitaxel analogue with a C-1β hydrogen substituent. Taxane 3 is an 2(3-→20)-abeo-taxane with a rare C-5 ketone and C-6 double bond.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalJournal of Natural Products
Volume69
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of '1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei'. Together they form a unique fingerprint.

  • Cite this

    Shi, Q. W., Zhao, Y. M., Si, X. T., Li, Z. P., Yamada, T., & Kiyota, H. (2006). 1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei. Journal of Natural Products, 69(2), 280-283. https://doi.org/10.1021/np0503451