Abstract
The conjugate addition of Me2CuLi to ethyl cinnamate derivatives bearing an alkynyl group at the ortho-position, took place preferentially in the presence of the corresponding α,β-unsaturated esters bearing an alkynyl group at the distal position or having no alkynyl groups. The observed chemoselectivity is most probably a reflection of the π-π chelation between π-electrons of the olefinic moiety of the enoates and those of the C-C triple bond located at the proximal position.
Original language | English |
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Pages (from-to) | 1803-1805 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 44 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2003 Feb 24 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry