δ-tocotrienol suppresses VEGF induced angiogenesis whereas α-tocopherol does not

Akira Shibata, Kiyotaka Nakagawa, Phumon Sookwong, Tsuyoshi Tsuduki, Shinichi Oikawa, Teruo Mlyazawa

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Recently, tocotrienol (T3), a less well-known form of vitamin E, has gained considerable attention as a potent antiangiogenic agent. However, the majority of vitamin E research has focused on tocopherol (Toe), with some studies indicating α-Toc may prevent tumor angiogenesis. In this study, we aimed to clarify the differences in antiangiogenic potential between δ-T3 and α-Toc. We showed δ-T3 (2.5-5 μM) completely abolished proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs), whereas a similar dose of α-Toc had no such effects. (δ-T3 suppressed VEGF receptor 2 (VEGFR-2) signaling, and activated caspases in HUVECs. In addition, via an in vivo mouse Matrigel plug angiogenesis assay, we found that δ-T3 (30 μg), but not α-Toc, inhibited tumor cell-induced vessel formation. In summary, our results demonstrate δ-T3 has superior antiangiogenic activities to α-Toc, and provide insights into the different mechanisms responsible for this effect of T3 and Toe.

Original languageEnglish
Pages (from-to)8696-8704
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number18
DOIs
Publication statusPublished - 2009 Sep 23

Keywords

  • Antlanglogenesls
  • Endothelial cell
  • Tocotrlenol
  • VEGF
  • Vitamin e

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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