γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Kumiko Sako, Hiroshi Aoyama, Shinichi Sato, Yuichi Hashimoto, Masanori Baba

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

Original languageEnglish
Pages (from-to)3780-3790
Number of pages11
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number7
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Keywords

  • Anti-BVDV agents
  • Thalidomide
  • γ-Carboline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity'. Together they form a unique fingerprint.

Cite this