γδ T cells: Firefighters or fire boosters in the front lines of inflammatory responses

Masanobu Nanno, Tetsuo Shiohara, Hiroshi Yamamoto, Kazuyoshi Kawakami, Hiromichi Ishikawa

Research output: Contribution to journalReview articlepeer-review

74 Citations (Scopus)

Abstract

Intradermal inoculation of cloned self-reactive αβ T cells into the footpads of mice induced cutaneous graft-versus-host disease (GVHD), and after recovery from GVHD, the epidermis became resistant to subsequent attempts to induce GVHD. Resistance to GVHD was not induced in the epidermis of T-cell receptor δ-deficient (TCRδ-/-) mice that lacked γδ T cells bearing canonical Vγ5/Vδ1+ γδTCRs, known as dendritic epidermal T cells (DETCs), and resistance was restored by reconstitution of these mutant mice with precursors of Vγ5+ DETCs. Pulmonary infection by Cryptococcus neoformans induced an increase of γδ T cells in the lung, and in comparison with wildtype mice, TCRδ-/- mice eliminated C. neoformans more rapidly and synthesized more interferon-γ in the lung. In the mouse small intestine, the absence of γδ T cells is associated with a reduction in epithelial cell turnover and downregulation of the expression of major histocompatibility complex class II molecules. The protective role of γδ T cells was verified in a dextran sodium sulfate-induced inflammatory bowel disease (IBD) model, whereas in a spontaneous model of IBD, γδ T cells were involved in the exacerbation of colitis in TCRα-/- mice. Taken together, in addition to the homeostatic regulation of epithelial tissues, γδ T cells appear to play a pivotal role in the modification of inflammatory responses induced in many organs containing epithelia.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalImmunological Reviews
Volume215
Issue number1
DOIs
Publication statusPublished - 2007 Feb

Keywords

  • Inflammatory bowel disease
  • Intestinal γδT cells
  • Pulmonary γδT cells
  • γδ DETC
  • γδ T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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