Nerve growth factor (NGF) is increased during inflammation and stress, Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of tile acute phase response which is mediated by cytokines. We now report the effect of systemic administration of β-NGF on levels of serum lipids and SAA. β-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, β-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, β-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.
|Number of pages||6|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - 1996 Feb 27|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology