β-nerve growth factor as a mediator of the acute phase response in vivo

Katsunori Nonogaki, Arthur H. Moser, Judy Shigenaga, Kenneth R. Feingold, Carl Grunfeld

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Nerve growth factor (NGF) is increased during inflammation and stress, Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of tile acute phase response which is mediated by cytokines. We now report the effect of systemic administration of β-NGF on levels of serum lipids and SAA. β-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, β-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, β-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.

Original languageEnglish
Pages (from-to)956-961
Number of pages6
JournalBiochemical and biophysical research communications
Volume219
Issue number3
DOIs
Publication statusPublished - 1996 Feb 27
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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