β-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: A randomized controlled trial

Yasuhisa Ano, Keiko Kobayashi, Mamoru Hanyuda, Ryuta Kawashima

Research output: Contribution to journalArticlepeer-review

Abstract

The number of elderly individuals with age-related cognitive decline or dementia is rapidly increasing. Dairy product consumption, including β-lactolin, is beneficial for their cognitive function. The underlying mechanism of β-lactolin's effects on human brain activity is yet to be investigated. We examined the β-lactolin effects on human cerebral blood flow (CBF) using near-infrared spectroscopy (NIRS) in a placebo-controlled randomized double-blind study, which reported according to the CONSORT guidelines. Fifty healthy participants (aged 45-60 years) were randomly allocated into the β-lactolin or the placebo group (n = 25 each) and supplemented for 6 weeks. During the 6th week, oxy-hemoglobin during the working memory tasks was measured using 34-channels (CHs) NIRS. The changes of oxy-hemoglobin, which represents the CBF, in CH 23 located at the left dorsolateral prefrontal cortex (DLPFC) during the spatial working memory task showed higher statistical significance (false discovery rate (q) = 0.045) in the β-lactolin than in the placebo group. The oxy-Hb changes in CH23 have a co-relationship with the working memory task reaction time. This clinical trial showed an increase in the CBF in the left DLPFC area during the 6-week β-lactolin supplementation. This study contributes to elucidating the underlying mechanisms of β-lactolin on cognitive performance.

Original languageEnglish
Pages (from-to)18660-18675
Number of pages16
JournalAging
Volume12
Issue number18
DOIs
Publication statusPublished - 2020 Sep 30

Keywords

  • Cerebral blood flow
  • Dorsolateral prefrontal cortex
  • Near-infrared spectroscopy (NIRS)
  • ß-lactolin
  • ß-lactopeptide

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

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