β-Isocupreidine-hexafluoroisopropyl acrylate method for asymmetric Baylis-Hillman reactions

Ayako Nakano, Sakie Kawahara, Saori Akamatsu, Kenji Morokuma, Mari Nakatani, Yoshiharu Iwabuchi, Keisuke Takahashi, Jun Ishihara, Susumi Hatakeyama

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

Key features of the β-isocupreidine (β-ICD)-catalyzed asymmetric Baylis-Hillman reaction of aldehydes with 1,1,1,3,3,3-hexafluoroisopropyl acrylate (HFIPA) are presented. In addition, an improved method using azeotropically dried β-ICD is described.

Original languageEnglish
Pages (from-to)381-389
Number of pages9
JournalTetrahedron
Volume62
Issue number2-3
DOIs
Publication statusPublished - 2006 Jan 9
Externally publishedYes

Keywords

  • 1,1,1,3,3,3-Hexafluoroisopropyl acrylate
  • Organic catalysis
  • β-Isocupreidine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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