β-Catenin/TCF/LEF regulate expression of the short form human Cripto-1

Shin Hamada, Kazuhide Watanabe, Morihisa Hirota, Caterina Bianco, Luigi Strizzi, Mario Mancino, Monica Gonzales, David S. Salomon

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/β-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalBiochemical and biophysical research communications
Volume355
Issue number1
DOIs
Publication statusPublished - 2007 Mar 30

Keywords

  • Cripto-1
  • Wnt
  • β-Catenin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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