α1,3-Fucoslytransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX

Mika Kaneko, Takashi Kudo, Hiroko Iwasaki, Yuzuru Ikehara, Shoko Nishihara, Satoshi Nakagawa, Katsutoshi Sasaki, Takashi Shiina, Hidetoshi Inoko, Naruya Saitou, Hisashi Narimatsu

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

The amino acid sequence of Fuc-TIX is very highly conserved between mouse and human. The number of non-synonymous nucleotide substitutions of the Fuc-TIX gene between human and mouse was strikingly low, and almost equivalent to that of the α-actin gene. This indicates that Fuc-TIX is under a strong selective pressure of preservation during evolution. The human Fuc-TIX (hFuc-TIX) showed a unique characteristics, i.e. hFuc-TIX was not activated by Mn2+ and Co2+, whereas hFuc-TIV and hFuc-TVI were activated by the cations. The hFuc-TIX transcripts were abundantly expressed in brain and stomach, and interestingly were detected in spleen and peripheral blood leukocytes. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalFEBS Letters
Volume452
Issue number3
DOIs
Publication statusPublished - 1999 Jun 11

Keywords

  • CD15
  • Fucosyltransferase
  • Glycosyltransferase
  • Lewis x
  • SSEA-1
  • α1,3-Fucosyltransferase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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