α-Synuclein oligomers pump it up!

Philipp J. Kahle, Naoto Sugeno, Angelos Skodras

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Oligomeric forms of the Parkinson's disease-causing protein α-synuclein are suspected to mediate neurodegeneration, but the mechanisms are not understood. The present study of Shrivastava et al.(2015) provides a fresh insight into this old mystery. α-Synuclein oligomers are shown by a combination of top state-of-the-art biochemical and super-resolution microscopy methods to sequester the neuronal sodium-potassium pump. Such perturbation of ion currents would ultimately lead to Ca2+ excitotoxicity. Oligomeric forms of the Parkinson's disease-causing protein α-synuclein sequester the neuronal sodium-potassium pump to perturb ion currents, ultimately leading to Ca2+ excitotoxicity.

Original languageEnglish
Pages (from-to)2385-2387
Number of pages3
JournalEMBO Journal
Volume34
Issue number19
DOIs
Publication statusPublished - 2015 Oct 1
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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