α-Arylation of Carbonyl Compounds through Oxidative C−C Bond Activation

Jing Li, Adriano Bauer, Giovanni Di Mauro, Nuno Maulide

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A synthetically useful approach for the direct α-arylation of carbonyl compounds through a novel oxidative C−C bond activation is reported. This mechanistically unusual process relies on a 1,2-aryl shift and results in all-carbon quaternary centers. The transformation displays broad functional-group tolerance and can in principle also be applied as an asymmetric variant.

Original languageEnglish
Pages (from-to)9816-9819
Number of pages4
JournalAngewandte Chemie - International Edition
Volume58
Issue number29
DOIs
Publication statusPublished - 2019 Jul 15

Keywords

  • C−C bond activation
  • arylation
  • enolonium species
  • ketones
  • umpolung

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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