α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements

Dilshan Balasuriya, Tom A. Goetze, Nelson P. Barrera, Andrew P. Stewart, Yuki Suzuki, J. Michael Edwardson

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Recent evidence has suggested that the various ionotropic glutamate receptors are assembled in the same way from their constituent subunits. Results: Atomic force microscopy imaging of antibody-decorated AMPA and NMDA receptors revealed different subunit arrangements. Conclusion: AMPA receptors have an alternating subunit arrangement, whereas NMDA receptors adopt an adjacent arrangement. Significance: Our results necessitate a reassessment of ionotropic glutamate receptor assembly.

Original languageEnglish
Pages (from-to)21987-21998
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
Publication statusPublished - 2013 Jul 26
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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