α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements

Dilshan Balasuriya; Tom A. Goetze; Nelson P. Barrera; Andrew P. Stewart; Yuki Suzuki; J. Michael Edwardson

doi:10.1074/jbc.M113.469205

α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements

Dilshan Balasuriya, Tom A. Goetze, Nelson P. Barrera, Andrew P. Stewart, Yuki Suzuki, J. Michael Edwardson

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Recent evidence has suggested that the various ionotropic glutamate receptors are assembled in the same way from their constituent subunits. Results: Atomic force microscopy imaging of antibody-decorated AMPA and NMDA receptors revealed different subunit arrangements. Conclusion: AMPA receptors have an alternating subunit arrangement, whereas NMDA receptors adopt an adjacent arrangement. Significance: Our results necessitate a reassessment of ionotropic glutamate receptor assembly.

Original language	English
Pages (from-to)	21987-21998
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.469205
Publication status	Published - 2013 Jul 26
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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AU - Goetze, Tom A.

AU - Barrera, Nelson P.

AU - Stewart, Andrew P.

AU - Suzuki, Yuki

AU - Edwardson, J. Michael

PY - 2013/7/26

Y1 - 2013/7/26

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AB - Background: Recent evidence has suggested that the various ionotropic glutamate receptors are assembled in the same way from their constituent subunits. Results: Atomic force microscopy imaging of antibody-decorated AMPA and NMDA receptors revealed different subunit arrangements. Conclusion: AMPA receptors have an alternating subunit arrangement, whereas NMDA receptors adopt an adjacent arrangement. Significance: Our results necessitate a reassessment of ionotropic glutamate receptor assembly.

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α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors adopt different subunit arrangements

Abstract

ASJC Scopus subject areas

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