• 3764 Citations
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1984 …2020

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2020

A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Waki, T., Mameda, R., Nakano, T., Yamada, S., Terashita, M., Ito, K., Tenma, N., Li, Y., Fujino, N., Uno, K., Yamashita, S., Aoki, Y., Denessiouk, K., Kawai, Y., Sugawara, S., Saito, K., Yonekura-Sakakibara, K., Morita, Y., Hoshino, A., Takahashi, S. & 1 others, Nakayama, T., 2020 Dec 1, In : Nature communications. 11, 1, 870.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

An Ambidextrous Polyphenol Glycosyltransferase PaGT2 from Phytolacca americana

Maharjan, R., Fukuda, Y., Shimomura, N., Nakayama, T., Okimoto, Y., Kawakami, K., Nakayama, T., Hamada, H., Inoue, T. & Ozaki, S. I., 2020 Jul 14, In : Biochemistry. 59, 27, p. 2551-2561 11 p.

Research output: Contribution to journalArticle

Open Access

Crown-ether-mediated crystal structures of the glycosyltransferase PaGT3 from Phytolacca americana

Maharjan, R., Fukuda, Y., Nakayama, T., Nakayama, T., Hamada, H., Ozaki, S. I. & Inoue, T., 2020 Jun 1, In : Acta Crystallographica Section D: Structural Biology. 76, p. 521-530 10 p.

Research output: Contribution to journalArticle

Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean

Imaizumi, R., Mameda, R., Takeshita, K., Kubo, H., Sakai, N., Nakata, S., Takahashi, S., Kataoka, K., Yamamoto, M., Nakayama, T., Yamashita, S. & Waki, T., 2020, (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journalArticle

Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside

Ono, E., Waki, T., Oikawa, D., Murata, J., Shiraishi, A., Toyonaga, H., Kato, M., Ogata, N., Takahashi, S., Yamaguchi, M. A., Horikawa, M. & Nakayama, T., 2020 Mar 1, In : Plant Journal. 101, 5, p. 1221-1233 13 p.

Research output: Contribution to journalArticle

The acid-base-nucleophile catalytic triad in ABH-fold enzymes is coordinated by a set of structural elements

Denesyuk, A., Dimitriou, P. S., Johnson, M. S., Nakayama, T. & Denessiouk, K., 2020 Feb 1, In : PloS one. 15, 2, e0229376.

Research output: Contribution to journalArticle

Open Access
2019

Distinctive structural motifs co-ordinate the catalytic nucleophile and the residues of the oxyanion hole in the alpha/beta-hydrolase fold enzymes

Dimitriou, P. S., Denesyuk, A. I., Nakayama, T., Johnson, M. S. & Denessiouk, K., 2019 Feb, In : Protein Science. 28, 2, p. 344-364 21 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Detection of acetaldehyde in the esophageal tissue among healthy male subjects after ethanol drinking and subsequent L-Cysteine intake

Okata, H., Hatta, W., Iijima, K., Asanuma, K., Tsuruya, A., Asano, N., Koike, T., Hamada, S., Nakayama, T., Masamune, A. & Shimosegawa, T., 2018 Apr, In : Tohoku Journal of Experimental Medicine. 244, 4, p. 317-325 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification and characterization of a novel bacterial β-glucosidase that is highly specific for the β-1,2-glucosidic linkage of sesaminol triglucoside

Sakurai, A., Hongo, S., Nair, A., Waki, T., Oikawa, D., Nishio, T., Shimoyama, T., Takahashi, S., Yamashita, S. & Nakayama, T., 2018, In : Bioscience, Biotechnology and Biochemistry. 82, 9, p. 1518-1521 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
13 Citations (Scopus)

Physical interactions among flavonoid enzymes in snapdragon and torenia reveal the diversity in the flavonoid metabolon organization of different plant species

Fujino, N., Tenma, N., Waki, T., Ito, K., Komatsuzaki, Y., Sugiyama, K., Yamazaki, T., Yoshida, S., Hatayama, M., Yamashita, S., Tanaka, Y., Motohashi, R., Denessiouk, K., Takahashi, S. & Nakayama, T., 2018 Apr, In : Plant Journal. 94, 2, p. 372-392 21 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Purification and characterization of small and large rubber particles from Hevea brasiliensis

Yamashita, S., Mizuno, M., Hayashi, H., Yamaguchi, H., Miyagi-Inoue, Y., Fushihara, K., Koyama, T., Nakayama, T. & Takahashi, S., 2018 Jan 1, In : Bioscience, Biotechnology and Biochemistry. 82, 6, p. 1011-1020 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Alpha/beta-hydrolases: A unique structural motif coordinates catalytic acid residue in 40 protein fold families

Dimitriou, P. S., Denesyuk, A., Takahashi, S., Yamashita, S., Johnson, M. S., Nakayama, T. & Denessiouk, K., 2017 Oct 1, In : Proteins: Structure, Function and Bioinformatics. 85, 10, p. 1845-1855 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2016

Developmental and nutritional regulation of isoflavone secretion from soybean roots

Sugiyama, A., Yamazaki, Y., Yamashita, K., Takahashi, S., Nakayama, T. & Yazaki, K., 2016 Jan 1, In : Bioscience, Biotechnology and Biochemistry. 80, 1, p. 89-94 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ecophysiological consequences of alcoholism on human gut microbiota: Implications for ethanol-related pathogenesis of colon cancer

Tsuruya, A., Kuwahara, A., Saito, Y., Yamaguchi, H., Tsubo, T., Suga, S., Inai, M., Aoki, Y., Takahashi, S., Tsutsumi, E., Suwa, Y., Morita, H., Kinoshita, K., Totsuka, Y., Suda, W., Oshima, K., Hattori, M., Mizukami, T., Yokoyama, A., Shimoyama, T. & 1 others, Nakayama, T., 2016 Jun 13, In : Scientific reports. 6, 27923.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Identification and reconstitution of the rubber biosynthetic machinery on rubber particles from Hevea brasiliensis

Yamashita, S., Yamaguchi, H., Waki, T., Aoki, Y., Mizuno, M., Yanbe, F., Ishii, T., Funaki, A., Tozawa, Y., Miyagi-Inoue, Y., Fushihara, K., Nakayama, T. & Takahashi, S., 2016 Oct 28, In : eLife. 5, OCTOBER2016, e19022.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Identification of protein-protein interactions of isoflavonoid biosynthetic enzymes with 2-hydroxyisoflavanone synthase in soybean (Glycine max (L.) Merr.)

Waki, T., Yoo, D. C., Fujino, N., Mameda, R., Denessiouk, K., Yamashita, S., Motohashi, R., Akashi, T., Aoki, T., Ayabe, S. I., Takahashi, S. & Nakayama, T., 2016 Jan 15, In : Biochemical and biophysical research communications. 469, 3, p. 546-551 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Major Anaerobic Bacteria Responsible for the Production of Carcinogenic Acetaldehyde from Ethanol in the Colon and Rectum

Tsuruya, A., Kuwahara, A., Saito, Y., Yamaguchi, H., Tenma, N., Inai, M., Takahashi, S., Tsutsumi, E., Suwa, Y., Totsuka, Y., Suda, W., Oshima, K., Hattori, M., Mizukami, T., Yokoyama, A., Shimoyama, T. & Nakayama, T., 2016 Jul 1, In : Alcohol and alcoholism (Oxford, Oxfordshire). 51, 4, p. 395-401 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Identification of a Highly Specific Isoflavone 7-O-glucosyltransferase in the soybean (Glycine max (L.) Merr.)

Funaki, A., Waki, T., Noguchi, A., Kawai, Y., Yamashita, S., Takahashi, S. & Nakayama, T., 2015 Aug 1, In : Plant and Cell Physiology. 56, 8, p. 1512-1520 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2014

CDNA cloning and characterization of chalcone isomerase-fold proteins from snapdragon (Antirrhinum majus L.) flowers

Fujino, N., Yamazaki, T., Li, Y., Kera, K., Furuhashi, E., Yamashita, S., Morita, Y., Nakayama, M., Takahashi, S. & Nakayama, T., 2014, In : Plant Biotechnology. 31, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Coordinated transcriptional regulation of isopentenyl diphosphate biosynthetic pathway enzymes in plastids by phytochrome-interacting factor 5

Mannen, K., Matsumoto, T., Takahashi, S., Yamaguchi, Y., Tsukagoshi, M., Sano, R., Suzuki, H., Sakurai, N., Shibata, D., Koyama, T. & Nakayama, T., 2014 Jan 10, In : Biochemical and biophysical research communications. 443, 2, p. 768-774 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Identification of laticifer-specific genes and their promoter regions from a natural rubber producing plant Hevea brasiliensis

Aoki, Y., Takahashi, S., Takayama, D., Ogata, Y., Sakurai, N., Suzuki, H., Asawatreratanakul, K., Wititsuwannakul, D., Wititsuwannakul, R., Shibata, D., Koyama, T. & Nakayama, T., 2014 Aug, In : Plant Science. 225, p. 1-8 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Paenibacillus relictisesami sp. nov., isolated from sesame oil cake

Shimoyama, T., Johari, N. B., Tsuruya, A., Nair, A. & Nakayama, T., 2014 Jan 1, In : International journal of systematic and evolutionary microbiology. 64, PART 5, p. 1534-1539 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structural insights into the low pH adaptation of a unique carboxylesterase from Ferroplasma: Altering the pH optima of two carboxylesterases

Ohara, K., Unno, H., Oshima, Y., Hosoya, M., Fujino, N., Hirooka, K., Takahashi, S., Yamashita, S., Kusunoki, M. & Nakayama, T., 2014 Jan 1, In : Journal of Biological Chemistry. 289, 35, p. 24499-24510 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1 Citation (Scopus)
2013

Crystallization and preliminary X-ray crystallographic analysis of UDP-glucuronic acid:flavonol-3-O-glucuronosyltransferase (VvGT5) from the grapevine Vitis vinifera

Mizohata, E., Okuda, T., Hatanaka, S., Nakayama, T., Horikawa, M., Nakayama, T., Ono, E. & Inoue, T., 2013 Jan, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 1, p. 65-68 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Glucosylation of hydroxyflavones by glucosyltransferases from Phytolacca americana

Iwakiri, T., Mase, S., Murakami, T., Matsumoto, M., Hamada, H., Nakayama, T. & Ozaki, S. I., 2013 Jun, In : Journal of Molecular Catalysis B: Enzymatic. 90, p. 61-65 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Purification, Gene Cloning, and Biochemical Characterization of a β-Glucosidase Capable of Hydrolyzing Sesaminol Triglucoside from Paenibacillus sp. KB0549

Nair, A., Kuwahara, A., Nagase, A., Yamaguchi, H., Yamazaki, T., Hosoya, M., Omura, A., Kiyomoto, K., Yamaguchi, M. A., Shimoyama, T., Takahashi, S. & Nakayama, T., 2013 Apr 10, In : PloS one. 8, 4, e60538.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of 3,5,3′,4′-tetrahydroxy-trans-stilbene-4′-O- β-dglucopyranoside by glucosyltransferases from Phytolacca americana

Iwakiri, T., Imai, H., Hamada, H., Nakayama, T. & Ozaki, S. I., 2013, In : Natural product communications. 8, 1, p. 119-120 2 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Transcription analyses of GmICHG, a gene coding for a β-glucosidase that catalyzes the specific hydrolysis of isoflavone conjugates in Glycine max (L.) Merr

Yoo, D. C., Hara, T., Fujita, N., Waki, T., Noguchi, A., Takahashi, S. & Nakayama, T., 2013 Jul 1, In : Plant Science. 208, p. 10-19 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Catalytic removal of acetaldehyde in saliva by a Gluconobacter strain

Yamaguchi, H., Hosoya, M., Shimoyama, T., Takahashi, S., Zhang, J. F., Tsutsumi, E., Suzuki, Y., Suwa, Y. & Nakayama, T., 2012 Sep 1, In : Journal of Bioscience and Bioengineering. 114, 3, p. 268-274 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana

Kera, K., Takahashi, S., Sutoh, T., Koyama, T. & Nakayama, T., 2012 Oct, In : FEBS Journal. 279, 20, p. 3813-3827 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Purification, characterization, and primary structure of a novel N-acyl-d-amino acid amidohydrolase from Microbacterium natoriense TNJL143-2

Liu, J., Asano, Y., Ikoma, K., Yamashita, S., Hirose, Y., Shimoyama, T., Takahashi, S., Nakayama, T. & Nishino, T., 2012 Oct, In : Journal of Bioscience and Bioengineering. 114, 4, p. 391-397 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Quantitative analyses of the behavior of exogenously added bacteria during an acidulocomposting process

Suematsu, T., Yamashita, S., Hemmi, H., Yoshinari, A., Shimoyama, T., Nakayama, T. & Nishino, T., 2012 Jul 1, In : Journal of Bioscience and Bioengineering. 114, 1, p. 70-72 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Regioselective glucosidation of trans-resveratrol in Escherichia coli expressing glucosyltransferase from Phytolacca americana

Ozaki, S. I., Imai, H., Iwakiri, T., Sato, T., Shimoda, K., Nakayama, T. & Hamada, H., 2012 Mar 1, In : Biotechnology Letters. 34, 3, p. 475-481 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The impact of plant secondary metabolic engineering

Nakayama, T., Chan, E. Y. & Seiji, T., 2012 Oct 17, In : Seibutsu-kogaku Kaishi. 90, 9, p. 576-581 6 p.

Research output: Contribution to journalArticle

2011

Gene cloning and biochemical characterization of a catalase from Gluconobacter oxydans

Yamaguchi, H., Sugiyama, K., Hosoya, M., Takahashi, S. & Nakayama, T., 2011 May 1, In : Journal of Bioscience and Bioengineering. 111, 5, p. 522-527 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2010

Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera)

Ono, E., Homma, Y., Horikawa, M., Kunikane-Doi, S., Imai, H., Takahashi, S., Kawai, Y., Ishiguro, M., Fukui, Y. & Nakayama, T., 2010 Aug, In : Plant Cell. 22, 8, p. 2856-2871 16 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Production of tetraketide lactones by mutated Antirrhinum majus chalcone synthases (AmCHS1)

Hatayama, M., Unno, H., Kusunoki, M., Takahashi, S., Nishino, T. & Nakayama, T., 2010 Aug 1, In : Journal of Bioscience and Bioengineering. 110, 2, p. 158-164 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2009

Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length

Noike, M., Katagiri, T., Nakayama, T., Nishino, T. & Hemmi, H., 2009 Mar 1, In : Journal of Bioscience and Bioengineering. 107, 3, p. 235-239 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of an inducible glucosyltransferase from Phytolacca americana L. cells that are capable of glucosylating capsaicin

Noguchi, A., Kunikane, S., Homma, H., Liu, W., Sekiya, T., Hosoya, M., Kwon, S., Ohiwa, S., Katsuragi, H., Nishino, T., Takahashi, S., Hamada, H. & Nakayama, T., 2009 Jan 1, In : Plant Biotechnology. 26, 3, p. 285-292 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1 Citation (Scopus)

Local differentiation of sugar donor specificity of flavonoid glycosyltransferase in lamiales W

Noguchi, A., Horikawa, M., Fukui, Y., Fukuchi-Mizutani, M., Iuchi-Okada, A., Ishiguro, M., Kiso, Y., Nakayama, T. & Onoa, E., 2009 May 1, In : Plant Cell. 21, 5, p. 1556-1572 17 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase

Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S. Y., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T. & Hemmi, H., 2009 Apr 3, In : Journal of Biological Chemistry. 284, 14, p. 9160-9167 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landfill leachate

Uchida, M., Hatayoshi, H., Syuku-nobe, A., Shimoyama, T., Nakayama, T., Okuwaki, A., Nishino, T. & Hemmi, H., 2009 May 30, In : Journal of Hazardous Materials. 164, 2-3, p. 1503-1508 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2008

A novel glucosylation enzyme: Molecular cloning, expression, and characterization of Trichoderma viride JCM22452 α-amylase and enzymatic synthesis of some flavonoid monoglucosides and oligoglucosides

Noguchi, A., Inohara-Ochiai, M., Ishibashi, N., Fukami, H., Nakayama, T. & Nakao, M., 2008 Dec 24, In : Journal of Agricultural and Food Chemistry. 56, 24, p. 12016-12024 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
16 Citations (Scopus)

The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction

Noike, M., Katagiri, T., Nakayama, T., Koyama, T., Nishino, T. & Hemmi, H., 2008 Aug 1, In : FEBS Journal. 275, 15, p. 3921-3933 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2007

Anthocyanin acyltransferase engineered for the synthesis of a novel polyacylated anthocyanin

Suzuki, H., Nishino, T. & Nakayama, T., 2007 Jan 1, In : Plant Biotechnology. 24, 5, p. 495-501 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
95 Citations (Scopus)