Shuntaro Ikawa

Associate Professor

  • 4521 Citations
  • 27 h-Index
1984 …2020

Research output per year

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Research Output

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Article
2020

Draxin-mediated Regulation of Granule Cell Progenitor Differentiation in the Postnatal Hippocampal Dentate Gyrus

Tawarayama, H., Yamada, H., Amin, R., Fujimura, Y., Cooper, H. M., Shinmyo, Y., Tanaka, H. & Ikawa, S., 2020 Apr 1, In : Neuroscience. 431, p. 184-192 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis

Tawarayama, H., Yamada, H., Amin, R., Morita-Fujimura, Y., Cooper, H. M., Shinmyo, Y., Kawata, M., Ikawa, S. & Tanaka, H., 2018 Dec 1, In : Scientific reports. 8, 1, 840.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis

Rashad, S., Niizuma, K., Sato-Maeda, M., Fujimura, M., Mansour, A., Endo, H., Ikawa, S. & Tominaga, T., 2018 Nov 15, In : Brain research. 1699, p. 54-68 15 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia

Rashad, S., Niizuma, K., Saigusa, D., Han, X., Sato-Maeda, M., Saito, R., Uruno, A., Fujimura, M., Ikawa, S., Yamamoto, M. & Tominaga, T., 2018 Aug 1, In : Neuroscience. 384, p. 188-202 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The chemorepellent draxin is involved in hippocampal mossy fiber projection

Tawarayama, H., Yamada, H., Shinmyo, Y., Tanaka, H. & Ikawa, S., 2018 Jun 2, In : Biochemical and biophysical research communications. 500, 2, p. 217-223 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017
5 Citations (Scopus)
2016

δNp63α induces quiescence and downregulates the BRCA1 pathway in estrogen receptor-positive luminal breast cancer cell line MCF7 but not in other breast cancer cell lines

Amin, R., Morita-Fujimura, Y., Tawarayama, H., Semba, K., Chiba, N., Fukumoto, M. & Ikawa, S., 2016 Apr 1, In : Molecular Oncology. 10, 4, p. 575-593 19 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Notch down-regulation in regenerated epidermis contributes to enhanced expression of interleukin-36α and suppression of keratinocyte differentiation during wound healing

Takazawa, Y., Ogawa, E., Saito, R., Uchiyama, R., Ikawa, S., Uhara, H. & Okuyama, R., 2015 Jul 1, In : Journal of dermatological science. 79, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2014

C-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage

Udden, S. M. N., Morita-Fujimura, Y., Satake, M. & Ikawa, S., 2014 Feb, In : Cellular Signalling. 26, 2, p. 444-452 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

Regulation of proliferation and differentiation of mouse tooth germ epithelial cells by distinct isoforms of p51/p63

Matsuura, T., Kawata, V. K. S., Nagoshi, H., Tomooka, Y., Sasaki, K. & Ikawa, S., 2012 Aug 1, In : Archives of Oral Biology. 57, 8, p. 1108-1115 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2011

Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-B signaling pathway

Ogawa, E., Owada, Y., Ikawa, S., Adachi, Y., Egawa, T., Nemoto, K., Suzuki, K., Hishinuma, T., Kawashima, H., Kondo, H., Muto, M., Aiba, S. & Okuyama, R., 2011 Mar, In : Journal of Investigative Dermatology. 131, 3, p. 604-612 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2010

Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes

Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K. & Okuyama, R., 2010 Jul 30, In : Journal of Biological Chemistry. 285, 31, p. 23581-23589 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2008

p51/p63 inhibits ultraviolet B-induced apoptosis via Akt activation

Ogawa, E., Okuyama, R., Ikawa, S., Nagoshi, H., Egawa, T., Kurihara, A., Yabuki, M., Tagami, H., Obinata, M. & Aiba, S., 2008 Jan 31, In : Oncogene. 27, 6, p. 848-856 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor

Ogawa, E., Okuyama, R., Egawa, T., Nagoshi, H., Obinata, M., Tagami, H., Ikawa, S. & Aiba, S., 2008 Dec 5, In : Journal of Biological Chemistry. 283, 49, p. 34241-34249 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2007

p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity

Okuyama, R., Ogawa, E., Nagoshi, H., Yabuki, M., Kurihara, A., Terui, T., Aiba, S., Obinata, M., Tagami, H. & Ikawa, S., 2007 Jul 5, In : Oncogene. 26, 31, p. 4478-4488 11 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: Multiple mechanisms of regulation of p53-dependent apoptosis

Kurihara, A., Nagoshi, H., Yabuki, M., Okuyama, R., Obinata, M. & Ikawa, S., 2007 Jul, In : Genes to Cells. 12, 7, p. 853-861 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2006

p51/p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate

Kunisaki, R., Ikawa, S., Maeda, T., Nakazaki, Y., Kurita, R., Harata, M., Shutoh, Y., Bai, Y. S., Soda, Y., Tanabe, T., Dohi, T., Kato, R., Ikawa, Y., Asano, S. & Tani, K., 2006 Sep 1, In : Journal of Gene Medicine. 8, 9, p. 1121-1130 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2005

Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA

Inoue, J. I., Yagi, S., Ishikawa, K., Azuma, S., Ikawa, S. & Semba, K., 2005 Sep 26, In : Gene. 358, 1-2, p. 53-59 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of DRG family regulatory proteins (DFRPs): Specific regulation of DRG1 and DRG2

Ishikawa, K., Azuma, S., Ikawa, S., Semba, K. & Inoue, J. I., 2005 Feb 1, In : Genes to Cells. 10, 2, p. 139-150 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis

Yoshizaki, F. Y., Ikawa, S., Satake, M., Satoh, N. & Nonaka, M., 2005 Mar 1, In : Immunogenetics. 56, 12, p. 930-942 13 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2004

Reporter gene stimulation by MIDA1 through its DnaJ homology region

Yoshida, M., Inoue, T., Shoji, W., Ikawa, S. & Obinata, M., 2004 Nov 5, In : Biochemical and biophysical research communications. 324, 1, p. 326-332 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

TIFAB inhibits TIFA, TRAF-interacting protein with a forkhead-associated domain

Matsumura, T., Semba, K., Azuma, S., Ikawa, S., Gohda, J., Akiyama, T. & Inoue, J. I., 2004 Apr 23, In : Biochemical and biophysical research communications. 317, 1, p. 230-234 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2003

Cloning and characterization of Xenopus laevis drg2, a member of the developmentally regulated GTP-binding protein subfamily

Ishikawa, K., Azuma, S., Ikawa, S., Morishita, Y., Gohda, J., Akiyama, T., Semba, K. & Inoue, J. I., 2003 Dec 11, In : Gene. 322, 1-2, p. 105-112 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)

Mori, K., Furusawa, T., Okubo, T., Inoue, T., Ikawa, S., Yanai, N., Mori, K. J. & Obinata, M., 2003 Apr 1, In : Journal of biochemistry. 133, 4, p. 405-413 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Hemocytes of Ciona intestinalis express multiple genes involved in innate immune host defense

Shida, K., Terajima, D., Uchino, R., Ikawa, S., Ikeda, M., Asano, K., Watanabe, T., Azumi, K., Nonaka, M., Satou, Y., Satoh, N., Satake, M., Kawazoe, Y. & Kasuya, A., 2003 Jan 10, In : Biochemical and biophysical research communications. 302, 2, p. 207-218 12 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Identification and Sequence of Seventy-nine New Transcripts Expressed in Hemocytes of Ciona intestinalis, Three of Which May Be Involved in Characteristic Cell-cell Communication

Terajima, D., Yamada, S., Uchino, R., Ikawa, S., Ikeda, M., Shida, K., Arai, Y., Wang, H. G., Satoh, N. & Satake, M., 2003, In : DNA Research. 10, 5, p. 203-212 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2002

Possible oncogenic potential of ΔNp73: A newly identified isoform of human p73

Ishimoto, O., Kawahara, C., Enjo, K., Obinata, M., Nukiwa, T. & Ikawa, S., 2002 Feb 1, In : Cancer Research. 62, 3, p. 636-641 6 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

Reversible switching of expression of c-kit and Pax-5 in immature hematopoietic progenitor cells by stromal cells

Okubo, T., Yanai, N., Ikawa, S. & Obinata, M., 2002 Oct 1, In : Experimental Hematology. 30, 10, p. 1193-1201 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2001

Mutation analysis of the p51 gene and correlation between p53, p73, and p51 expressions in prostatic carcinoma

Takahashi, H., Fukutome, K., Watanabe, M., Furusato, M., Shiraishi, T., Ito, H., Suzuki, H., Ikawa, S. & Hano, H., 2001 May 1, In : Prostate. 47, 2, p. 85-90 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2000

Absence of p51 mutation in human hepatocellular carcinoma

Hamada, K., Koyama, T., Shimizu, K., Ikawa, S., Kawate, S., Yokota, J., Ohwada, S. & Morishita, Y., 2000 Feb 1, In : Cancer Letters. 148, 2, p. 161-164 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

Marin, M. C., Jost, C. A., Brooks, L. A., Irwin, M. S., O'Nions, J., Tidy, J. A., James, N., McGregor, J. M., Harwood, C. A., Yulug, I. G., Vousden, K. H., Allday, M. J., Gusterson, B., Ikawa, S., Hinds, P. W., Crook, T. & Kaelin, W. G., 2000 May, In : Nature Genetics. 25, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

450 Citations (Scopus)

Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein

Kaida, A., Ariumi, Y., Ueda, Y., Lin, J. Y., Hijikata, M., Ikawa, S. & Shimotohno, K., 2000 Feb 10, In : Oncogene. 19, 6, p. 827-830 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Isolation of a novel PDZ-containing myosin from hematopoietic supportive bone marrow stromal cell lines

Furusawa, T., Ikawa, S., Yanai, N. & Obinata, M., 2000 Apr 2, In : Biochemical and biophysical research communications. 270, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

p51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation

Katoh, I., Aisaki, K. I., Kurata, S. I., Ikawa, S. & Ikawa, Y., 2000 Jun 22, In : Oncogene. 19, 27, p. 3126-3130 5 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)
1999

Effects of p51/p63 missense mutations on transcriptional activities of p53 downstream gene promoters

Kato, S., Shimada, A., Osada, M., Ikawa, S., Obinata, M., Nakagawara, A., Kanamaru, R. & Ishioka, C., 1999 Dec 1, In : Cancer Research. 59, 23, p. 5908-5911 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Human p53-p51 (p53-related) fusion protein: A potent BAX transactivator

Ikawa, S., Obinata, M. & Ikawa, Y., 1999 Jun, In : Japanese Journal of Cancer Research. 90, 6, p. 596-599 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Influence of p53 mutation on pathological grade, but not prognosis of non-Hodgkin's lymphoma

Osada, M., Ishioka, C., Ichinohasama, R., Kadowaki, I., Murakawa, Y., Watanabe, M., Kanamaru, R. & Ikawa, S., 1999 Apr, In : Anti-Cancer Drug Design. 14, 2, p. 107-114 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Mutational analysis of p51A/TAp63γ, a p53 homolog, in non-small cell lung cancer and breast cancer

Sunahara, M., Shishikura, T., Takahashi, M., Todo, S., Yamamoto, N., Kimura, H., Kato, S., Ishioka, C., Ikawa, S., Ikawa, Y. & Nakagawara, A., 1999 Jun 24, In : Oncogene. 18, 25, p. 3761-3765 5 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Mutation and expression of the p51 gene in human lung cancer.

Tani, M., Shimizu, K., Kawahara, C., Kohno, T., Ishimoto, O., Ikawa, S. & Yokota, J., 1999 Apr, In : Neoplasia (New York, N.Y.). 1, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

p53 Is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression

Ruiz-Lozano, P., Hixon, M. L., Wagner, M. W., Flores, A. I., Ikawa, S., Baldwin, A. S., Chien, K. R. & Gualberto, A., 1999 May, In : Cell Growth and Differentiation. 10, 5, p. 295-306 12 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

The transcriptional activities of p53 and its homologue p51/p63: Similarities and differences

Shimada, A., Kato, S., Enjo, K., Osada, M., Ikawa, Y., Kohno, K., Obinata, M., Kanamaru, R., Ikawa, S. & Ishioka, C., 1999 Jun 15, In : Cancer Research. 59, 12, p. 2781-2786 6 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)
1998

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M. & Ikawa, S., 1998 Jul 1, In : Nature Medicine. 4, 7, p. 839-843 5 p.

Research output: Contribution to journalArticle

459 Citations (Scopus)

The Ah receptor is not involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin- mediated apoptosis in human leukemic T cell lines

Hossain, A., Tsuchiya, S., Minegishi, M., Osada, M., Ikawa, S., Tezuka, F. A., Kaji, M., Konno, T., Watanabe, M. & Kikuchi, H., 1998 Jul 31, In : Journal of Biological Chemistry. 273, 31, p. 19853-19858 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
1997

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

Kimpara, T., Takeda, A., Watanabe, K., Itoyama, Y., Ikawa, S., Watanabe, M., Arai, H., Sasaki, H., Higuchi, S., Okita, N., Takase, S., Saito, H., Takahashi, K. & Shibahara, S., 1997 Jul, In : Human Genetics. 100, 1, p. 145-147 3 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

p53 Mutation does not determine prognosis in non-hodgkin's lymphoma

Osada, M., Ishioka, C., Murakawa, Y., Ichinohasama, R., Kanamaru, R. & Ikawa, S., 1997 Sep 24, In : Japanese Journal of Cancer and Chemotherapy. 24, 4, p. 471-475 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Screening the p53 status of human cell lines using a yeast functional assay

Jia, L. Q., Osada, M., Ishioka, C., Gamo, M., Ikawa, S., Suzuki, T., Shimodaira, H., Niitani, T., Kudo, T., Akiyama, M., Kimura, N., Matsuo, M., Mizusawa, H., Tanaka, N., Koyama, H., Namba, M., Kanamaru, R. & Kuroki, T., 1997 Sep 26, In : Molecular Carcinogenesis. 19, 4, p. 243-253 11 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)
1996

Differences in inducibility of CYP1A1-mRNA by benzimidazole compounds between human and mouse cells: Evidences of a human-specific signal transduction pathway for CYP1A1 induction

Kikuchi, H., Kato, H., Mizuno, M., Hossain, A., Ikawa, S., Miyazaki, J. & Watanabe, M., 1996 Oct 15, In : Archives of Biochemistry and Biophysics. 334, 2, p. 235-240 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

Ema, M., Morita, M., Ikawa, S., Tanaka, M., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., Kikuchi, Y. & Fujii-Kuriyama, Y., 1996, In : Molecular and cellular biology. 16, 10, p. 5865-5875 11 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)
1995

Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism

Ikawa, S., Uematsu, F., Watanabe, K. I., Kimpara, T., Osada, M., Hossain, A., Sagami, I., Kikuchi, H. & Watanabe, M., 1995 Dec, In : Pharmacogenetics. 5, p. S154-S160

Research output: Contribution to journalArticle

20 Citations (Scopus)