• 1938 Citations
  • 28 h-Index
19982020

Research output per year

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Research Output

  • 1938 Citations
  • 28 h-Index
  • 72 Article
  • 8 Review article
  • 2 Comment/debate
2020

Kir6.1 Heterozygous Mice Exhibit Aberrant Amygdala-Dependent Cued Fear Memory

Inagaki, R., Moriguchi, S. & Fukunaga, K., 2020 Mar 1, In : Molecular Neurobiology. 57, 3, p. 1622-1635 14 p.

Research output: Contribution to journalArticle

Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice

Moriguchi, S., Inagaki, R., Shimojo, H., Sugimura, Y. & Fukunaga, K., 2020 Aug 21, In : Neuroscience. 442, p. 264-273 10 p.

Research output: Contribution to journalArticle

Nicotine Rescues Depressive-like Behaviors via α7-type Nicotinic Acetylcholine Receptor Activation in CaMKIV Null Mice

Moriguchi, S., Inagaki, R., Yi, L., Shibata, M., Sakagami, H. & Fukunaga, K., 2020, (Accepted/In press) In : Molecular Neurobiology. 57, 12, p. 4929-4940 12 p.

Research output: Contribution to journalArticle

2019

Aberrant Amygdala-Dependent Cued Fear Memory in Na + /Ca 2+ Exchanger 1 Heterozygous Mice

Moriguchi, S., Kita, S., Inagaki, R., Yabuki, Y., Sasaki, Y., Ishikawa, S., Sakagami, H., Iwamoto, T. & Fukunaga, K., 2019 Jun 1, In : Molecular Neurobiology. 56, 6, p. 4381-4394 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Aberrant Amygdala-dependent Fear Memory in Corticosterone-treated Mice

Inagaki, R., Moriguchi, S. & Fukunaga, K., 2018 Sep 15, In : Neuroscience. 388, p. 448-459 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Blockade of the K ATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy

Moriguchi, S., Ishizuka, T., Yabuki, Y., Shioda, N., Sasaki, Y., Tagashira, H., Yawo, H., Yeh, J. Z., Sakagami, H., Narahashi, T. & Fukunaga, K., 2018 Feb 1, In : Molecular psychiatry. 23, 2, p. 211-221 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dysfunction of na + /ca 2+ exchangers is associated with cognitive decline in alzheimer’s disease

Moriguchi, S., Kita, S., Iwamoto, T. & Fukunaga, K., 2018 Jan 1, In : Folia Pharmacologica Japonica. 152, 6, p. 299-305 7 p.

Research output: Contribution to journalArticle

Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice

Moriguchi, S., Kita, S., Yabuki, Y., Inagaki, R., Izumi, H., Sasaki, Y., Tagashira, H., Horie, K., Takeda, J., Iwamoto, T. & Fukunaga, K., 2018 May 1, In : Molecular Neurobiology. 55, 5, p. 3889-3900 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice

Moriguchi, S., Kita, S., Fukaya, M., Osanai, M., Inagaki, R., Sasaki, Y., Izumi, H., Horie, K., Takeda, J., Saito, T., Sakagami, H., Saido, T. C., Iwamoto, T. & Fukunaga, K., 2018 Mar 15, In : Neuropharmacology. 131, p. 291-303 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2017

Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice

Yabuki, Y., Matsuo, K., Hirano, K., Shinoda, Y., Moriguchi, S. & Fukunaga, K., 2017 Mar 1, In : Pharmacology. 99, 3-4, p. 160-171 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Memantine improves cognitive function via KATP channel inhibition

Moriguchi, S. & Fukunaga, K., 2017 Jan 1, In : Folia Pharmacologica Japonica. 150, 5, p. 228-233 6 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)
2016

A novel therapeutic target of treatment-resistant depression

Moriguchi, S., 2016 Aug, In : Japanese Journal of Neuropsychopharmacology. 36, 4, p. 73-78 6 p.

Research output: Contribution to journalReview article

Functional Genomic Analyses Identify Pathways Dysregulated in Animal Model of Autism

Huang, J. Y., Tian, Y., Wang, H. J., Shen, H., Wang, H., Long, S., Liao, M. H., Liu, Z. R., Wang, Z. M., Li, D., Tao, R. R., Cui, T. T., Moriguchi, S., Fukunaga, K., Han, F. & Lu, Y. M., 2016 Oct 1, In : CNS Neuroscience and Therapeutics. 22, 10, p. 845-853 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

Aberrant Behavioral Sensitization by Methamphetamine in Junctophilin-Deficient Mice

Moriguchi, S., Nishi, M., Sasaki, Y., Takeshima, H. & Fukunaga, K., 2015 Jan 1, In : Molecular Neurobiology. 51, 2, p. 533-542 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice

Moriguchi, S., Sakagami, H., Yabuki, Y., Sasaki, Y., Izumi, H., Zhang, C., Han, F. & Fukunaga, K., 2015 Dec 1, In : Molecular Neurobiology. 52, 3, p. 1210-1222 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice

Murata, K., Yoshino, Y., Tsuruma, K., Moriguchi, S., Oyagi, A., Tanaka, H., Ishisaka, M., Shimazawa, M., Fukunaga, K. & Hara, H., 2015 Mar 1, In : Journal of Neurochemistry. 132, 5, p. 583-594 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2014

CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment

Moriguchi, S., Tagashira, H., Sasaki, Y., Yeh, J. Z., Sakagami, H., Narahashi, T. & Fukunaga, K., 2014 Mar, In : Journal of Neurochemistry. 128, 6, p. 927-937 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
1 Citation (Scopus)

Melatonin reverses the decreases in hippocampal protein serine/threonine kinases observed in an animal model of autism

Tian, Y., Yabuki, Y., Moriguchi, S., Fukunaga, K., Mao, P. J., Hong, L. J., Lu, Y. M., Wang, R., Ahmed, M. M., Liao, M. H., Huang, J. Y., Zhang, R. T., Zhou, T. Y., Long, S. & Han, F., 2014 Jan, In : Journal of Pineal Research. 56, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Rivastigmine improves hippocampal neurogenesis and depression-like behaviors via 5-HT1A receptor stimulation in olfactory bulbectomized mice

Islam, M. R., Moriguchi, S., Tagashira, H. & Fukunaga, K., 2014 Jul 11, In : Neuroscience. 272, p. 116-130 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2013

Decreased CaMKII and PKC activities in specific brain regions are associated with cognitive impairment in neonatal ventral hippocampus-lesioned rats

Yabuki, Y., Nakagawasai, O., Moriguchi, S., Shioda, N., Onogi, H., Tan-No, K., Tadano, T. & Fukunaga, K., 2013 Mar 7, In : Neuroscience. 234, p. 103-115 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor

Moriguchi, S., Tanaka, T., Narahashi, T. & Fukunaga, K., 2013 Oct, In : Hippocampus. 23, 10, p. 942-951 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice

Moriguchi, S., Tanaka, T., Tagashira, H., Narahashi, T. & Fukunaga, K., 2013 Apr 1, In : Behavioural Brain Research. 242, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stimulation of the Sigma-1 Receptor by DHEA Enhances Synaptic Efficacy and Neurogenesis in the Hippocampal Dentate Gyrus of Olfactory Bulbectomized Mice

Moriguchi, S., Shinoda, Y., Yamamoto, Y., Sasaki, Y., Miyajima, K., Tagashira, H. & Fukunaga, K., 2013 Apr 8, In : PloS one. 8, 4, e60863.

Research output: Contribution to journalArticle

51 Citations (Scopus)
26 Citations (Scopus)

Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor beta-receptor lacking mice

Shioda, N., Moriguchi, S., Oya, T., Ishii, Y., Shen, J., Matsushima, T., Nishijo, H., Sasahara, M. & Fukunaga, K., 2012 Jun, In : Hippocampus. 22, 6, p. 1371-1378 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
45 Citations (Scopus)
43 Citations (Scopus)
2011

Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy

Moriguchi, S., Oomura, Y., Shioda, N., Han, F., Hori, N., Aou, S. & Fukunaga, K., 2011 Jan 1, In : Molecular and Cellular Neuroscience. 46, 1, p. 101-107 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation

Oyagi, A., Moriguchi, S., Nitta, A., Murata, K., Oida, Y., Tsuruma, K., Shimazawa, M., Fukunaga, K. & Hara, H., 2011 Oct 24, In : Brain research. 1419, p. 97-104 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Neurochemical mechanisms of a novel Alzheimer's disease therapeutics on improvement of cognition and depressive behavior

Shioda, N., Yamamoto, Y., Han, F., Moriguchi, S. & Fukunaga, K., 2011 Apr 11, In : Yakugaku Zasshi. 131, 4, p. 505-511 7 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Pharmacological study on Alzheimer's drugs targeting calcium/calmodulin- dependent protein kinase II

Moriguchi, S., 2011 Sep 22, In : Journal of Pharmacological Sciences. 117, 1, p. 6-11 6 p.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Prandial increases of leptin and orexin in the brain modulate spatial learning and memory

Oomura, Y., Aou, S., Fukunaga, K., Moriguchi, S. & Sasaki, K., 2011 Mar, In : Neuroscience and Behavioral Physiology. 41, 3, p. 233-242 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice

Nogami, T., Beppu, H., Tokoro, T., Moriguchi, S., Shioda, N., Fukunaga, K., Ohtsuka, T., Ishii, Y., Sasahara, M., Shimada, Y., Nishijo, H., Li, E. & Kitajima, I., 2011 Jun, In : Hippocampus. 21, 6, p. 678-687 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
49 Citations (Scopus)
2010

A novel cognitive enhancer, ZSET1446/ST101, promotes hippocampal neurogenesis and ameliorates depressive behavior in olfactory bulbectomized mice

Shioda, N., Yamamoto, Y., Han, F., Moriguchi, S., Yamaguchi, Y., Hino, M. & Fukunaga, K., 2010 Apr 1, In : Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice

Yamamoto, Y., Shioda, N., Han, F., Moriguchi, S. & Fukunaga, K., 2010 May 1, In : Yakugaku Zasshi. 130, 5, p. 717-721 5 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKβ in neurite spine formation, contributing to cognitive function

Shirai, Y., Kouzuki, T., Kakefuda, K., Moriguchi, S., Oyagi, A., Horie, K., Morita, S. Y., Shimazawa, M., Fukunaga, K., Takeda, J., Saito, N. & Hara, H., 2010 Jul 15, In : PloS one. 5, 7, e11602.

Research output: Contribution to journalArticle

59 Citations (Scopus)
10 Citations (Scopus)

Prandial increases of leptin and orexin in the brain modulate spatial learning and memory

Oomura, Y., Aou, S., Fukunaga, K., Moriguchi, S. & Sasaki, K., 2010 Jul 8, In : Hirosaki Medical Journal. 61, SUPPL., p. S1-S10

Research output: Contribution to journalArticle

The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells

Liu, Q. B., Liu, L. L., Lu, Y. M., Tao, R. R., Huang, J. Y., Shioda, N., Moriguchi, S., Fukunaga, K., Han, F. & Lou, Y. J., 2010 May 1, In : Toxicology and Applied Pharmacology. 244, 3, p. 374-384 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2009

Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation

Moriguchi, S., Shioda, N., Han, F., Yeh, J. Z., Narahashi, T. & Fukunaga, K., 2009 Sep, In : Hippocampus. 19, 9, p. 844-854 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice

Oyagi, A., Oida, Y., Kakefuda, K., Shimazawa, M., Shioda, N., Moriguchi, S., Kitaichi, K., Nanba, D., Yamaguchi, K., Furuta, Y., Fukunaga, K., Higashiyama, S. & Hara, H., 2009 Oct 14, In : PloS one. 4, 10, e7461.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice

Moriguchi, S., Han, F., Shioda, N., Yamamoto, Y., Nakajima, T., Nakagawasai, O., Tadano, T., Yeh, J. Z., Narahashi, T. & Fukunaga, K., 2009 Jul, In : Journal of Neurochemistry. 110, 1, p. 170-181 12 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons

Moriguchi, S., Zhao, X., Marszalec, W., Yeh, J. Z., Fukunaga, K. & Narahashi, T., 2009 May 5, In : Neuroscience. 160, 2, p. 484-491 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

Yamamoto, Y., Shioda, N., Han, F., Moriguchi, S., Nakajima, A., Yokosuka, A., Mimaki, Y., Sashida, Y., Yamakuni, T., Ohizumi, Y. & Fukunaga, K., 2009 Oct 12, In : Brain research. 1295, p. 218-229 12 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
14 Citations (Scopus)