• 1438 Citations
  • 20 h-Index
20062020

Research output per year

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Research Output

  • 1438 Citations
  • 20 h-Index
  • 61 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins

Yamashita, H., Tomoshige, S., Nomura, S., Ohgane, K., Hashimoto, Y. & Ishikawa, M., 2020 Jan 1, In : Bioorganic and Medicinal Chemistry. 28, 1, 115175.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

生細胞内の疾患関連タンパク質を 減少させる低分子創薬手法の開発

Translated title of the contribution: Degradation of disease related proteins in living cells by small moleculesIshikawa, M. & Hashimoto, Y., 2020 Jan 1, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 78, 5, p. 402-413 12 p.

Research output: Contribution to journalArticle

2018

Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

Tomoshige, S., Nomura, S., Ohgane, K., Hashimoto, Y. & Ishikawa, M., 2018 Feb 15, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 707-710 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton

Nishiyama, Y., Fujii, S., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2018 Jul 18, In : International journal of molecular sciences. 19, 7, 2090.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

Nishiyama, Y., Mori, S., Makishima, M., Fujii, S., Kagechika, H., Hashimoto, Y. & Ishikawa, M., 2018 Jul 12, In : ACS Medicinal Chemistry Letters. 9, 7, p. 641-645 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility

Nomura, S., Endo-Umeda, K., Fujii, S., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2018 Feb 15, In : Bioorganic and Medicinal Chemistry Letters. 28, 4, p. 796-801 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands

Shioi, R., Toyota, Y., Noguchi-Yachide, T., Ishikawa, M., Yamaguchi, T., Makishima, M., Hashimoto, Y. & Ohgane, K., 2018 Jan 1, In : Heterocycles. 97, 2, p. 854-864 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators

Endo-Umeda, K., Aoyama, A., Shimizu, M., Ishikawa, M., Hashimoto, Y., Yamada, S. & Makishima, M., 2017 Sep, In : Journal of Steroid Biochemistry and Molecular Biology. 172, p. 136-148 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Discovery of Small Molecules that Induce the Degradation of Huntingtin

Tomoshige, S., Nomura, S., Ohgane, K., Hashimoto, Y. & Ishikawa, M., 2017 Jan 1, In : Angewandte Chemie - International Edition. 56, 38, p. 11530-11533 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein

Fukuda, H., Karaki, F., Dodo, K., Noguchi-Yachide, T., Ishikawa, M., Hashimoto, Y. & Ohgane, K., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 12, p. 2781-2787 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Photo-enhanced Aqueous Solubilization of an Azo-compound

Ishikawa, M., Ohzono, T., Yamaguchi, T. & Norikane, Y., 2017 Dec 1, In : Scientific reports. 7, 1, 6909.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate

Chiba, K., Asanuma, M., Ishikawa, M., Hashimoto, Y., Dodo, K., Sodeoka, M. & Yamaguchi, T., 2017, In : Chemical Communications. 53, 62, p. 8751-8754 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

Sato, Y., Okatsu, K., Saeki, Y., Yamano, K., Matsuda, N., Kaiho, A., Yamagata, A., Goto-Ito, S., Ishikawa, M., Hashimoto, Y., Tanaka, K. & Fukai, S., 2017 Nov 1, In : Nature Structural and Molecular Biology. 24, 11, p. 911-919 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Structural development studies of pyrazoloketone-derived acetyl-CoA carboxylase inhibitors

Okazaki, S., Sakai, T., Ishikawa, M., Hashimoto, Y. & Yamaguchi, T., 2017 Jan 1, In : Heterocycles. 95, 1, p. 595-607 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression

Toyota, Y., Nomura, S., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 12, p. 2776-2780 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists

Shioi, R., Okazaki, S., Noguchi-Yachide, T., Ishikawa, M., Makishima, M., Hashimoto, Y. & Yamaguchi, T., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3131-3134 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules

Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M., 2017 Mar, In : Molecular pharmacology. 91, 3, p. 159-166 8 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)
2016

Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists

Nomura, S., Endo-Umeda, K., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2016 Jan 1, In : ChemMedChem. 11, 20, p. 2347-2360 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity

Okazaki, S., Noguchi-Yachide, T., Sakai, T., Ishikawa, M., Makishima, M., Hashimoto, Y. & Yamaguchi, T., 2016 Jan 1, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5258-5269 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
16 Citations (Scopus)

Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure

Hiramatsu, M., Ichikawa, Y., Tomoshige, S., Makishima, M., Muranaka, A., Uchiyama, M., Yamaguchi, T., Hashimoto, Y. & Ishikawa, M., 2016 Aug 5, In : Chemistry - An Asian Journal. 11, 15, p. 2210-2217 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structure–activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists

Okazaki, S., Shioi, R., Noguchi-Yachide, T., Ishikawa, M., Makishima, M., Hashimoto, Y. & Yamaguchi, T., 2016 Jan 1, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5455-5461 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules

Tomoshige, S., Naito, M., Hashimoto, Y. & Ishikawa, M., 2015 Aug 24, In : Organic and Biomolecular Chemistry. 13, 38, p. 9746-9750 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton

Sakai, T., Matsumoto, Y., Ishikawa, M., Sugita, K., Hashimoto, Y., Wakai, N., Kitao, A., Morishita, E., Toyoshima, C., Hayashi, T. & Akiyama, T., 2015 Jan 15, In : Bioorganic and Medicinal Chemistry. 23, 2, p. 328-339 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists

Kajita, D., Nakamura, M., Matsumoto, Y., Ishikawa, M., Hashimoto, Y. & Fujii, S., 2015 Jul 3, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3350-3354 5 p., 22735.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structure-activity relationships of benzhydrol derivatives based on 1′-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway

Misawa, T., Dodo, K., Ishikawa, M., Hashimoto, Y., Sagawa, M., Kizaki, M. & Aoyama, H., 2015 May 1, In : Bioorganic and Medicinal Chemistry. 23, 9, p. 2241-2246 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

Nomura, S., Endo-Umeda, K., Aoyama, A., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2015 Aug 13, In : ACS Medicinal Chemistry Letters. 6, 8, p. 902-907 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2014

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity

Endo-Umeda, K., Yasuda, K., Sugita, K., Honda, A., Ohta, M., Ishikawa, M., Hashimoto, Y., Sakaki, T. & Makishima, M., 2014 Mar, In : Journal of Steroid Biochemistry and Molecular Biology. 140, p. 7-16 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand

Nishiyama, Y., Nakamura, M., Misawa, T., Nakagomi, M., Makishima, M., Ishikawa, M. & Hashimoto, Y., 2014 May 1, In : Bioorganic and Medicinal Chemistry. 22, 9, p. 2799-2808 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013
2 Citations (Scopus)

Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Mita, Y., Noguchi-Yachide, T., Ishikawa, M. & Hashimoto, Y., 2013 Feb 1, In : Bioorganic and Medicinal Chemistry. 21, 3, p. 608-617 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators

Mita, Y., Dodo, K., Noguchi-Yachide, T., Hashimoto, Y. & Ishikawa, M., 2013 Feb 15, In : Bioorganic and Medicinal Chemistry. 21, 4, p. 993-1005 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Structure-activity relationships of bisphenol a analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist

Maruyama, K., Nakamura, M., Tomoshige, S., Sugita, K., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2013 Jul 15, In : Bioorganic and Medicinal Chemistry Letters. 23, 14, p. 4031-4036 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2012

Design, synthesis, and biological evaluation of novel transrepression- selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11- methylene-6 H-dibenz[ b, e ]azepin-6-one skeleton

Aoyama, A., Endo-Umeda, K., Kishida, K., Ohgane, K., Noguchi-Yachide, T., Aoyama, H., Ishikawa, M., Miyachi, H., Makishima, M. & Hashimoto, Y., 2012 Sep 13, In : Journal of Medicinal Chemistry. 55, 17, p. 7360-7377 18 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist

Itoh, Y., Ishikawa, M., Kitaguchi, R., Okuhira, K., Naito, M. & Hashimoto, Y., 2012 Jul 1, In : Bioorganic and Medicinal Chemistry Letters. 22, 13, p. 4453-4457 5 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2011

Confirmation of molecular planarity disruption effect on aqueous solubility improvement of β-naphthoflavone analogs

Fujita, Y., Yonehara, M., Kitahara, K., Shimokawa, J., Hashimoto, Y. & Ishikawa, M., 2011 Oct 31, In : Heterocycles. 83, 11, p. 2563-2575 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Itoh, Y., Kitaguchi, R., Ishikawa, M., Naito, M. & Hashimoto, Y., 2011 Nov 15, In : Bioorganic and Medicinal Chemistry. 19, 22, p. 6768-6778 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Development of target protein-selective degradation inducer for protein knockdown

Itoh, Y., Ishikawa, M., Kitaguchi, R., Sato, S., Naito, M. & Hashimoto, Y., 2011 May 15, In : Bioorganic and Medicinal Chemistry. 19, 10, p. 3229-3241 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry

Ishikawa, M. & Hashimoto, Y., 2011 Mar 24, In : Journal of Medicinal Chemistry. 54, 6, p. 1539-1554 16 p.

Research output: Contribution to journalArticle

275 Citations (Scopus)

Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide

Motoshima, K., Ishikawa, M., Hashimoto, Y. & Sugita, K., 2011 Jul, In : Chemical and Pharmaceutical Bulletin. 59, 7, p. 880-884 5 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
13 Citations (Scopus)
11 Citations (Scopus)

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

Okuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y. & Naito, M., 2011 Apr 20, In : FEBS Letters. 585, 8, p. 1147-1152 6 p.

Research output: Contribution to journalArticle

Open Access
71 Citations (Scopus)
2010

Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide

Iwai, Y., Takahashi, H., Hatakeyama, D., Motoshima, K., Ishikawa, M., Sugita, K., Hashimoto, Y., Harada, Y., Itamura, S., Odagiri, T., Tashiro, M., Sei, Y., Yamaguchi, K. & Kuzuhara, T., 2010 Jul 15, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5379-5390 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Development of tryptase inhibitors derived from thalidomide

Tetsuhashi, M., Ishikawa, M., Hashimoto, M., Hashimoto, Y. & Aoyama, H., 2010 Jul 15, In : Bioorganic and Medicinal Chemistry. 18, 14, p. 5323-5338 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Further application of the multi-template approach for creation of biological response modifiers: Discovery of a new class of multifunctional anti-diabetic agents

Motoshima, K., Noguchi-Yachide, T., Ishikawa, M., Hashimoto, Y. & Sugita, K., 2010 Feb 28, In : Heterocycles. 82, 2, p. 1083-1101 19 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry

Kasuga, J. I., Ishikawa, M., Yonehara, M., Makishima, M., Hashimoto, Y. & Miyachi, H., 2010 Oct 15, In : Bioorganic and Medicinal Chemistry. 18, 20, p. 7164-7173 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators

Mita, Y., Dodo, K., Noguchi-Yachide, T., Miyachi, H., Makishima, M., Hashimoto, Y. & Ishikawa, M., 2010 Mar 1, In : Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1712-1717 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Novel selective anti-androgens with a diphenylpentane skeleton

Maruyama, K., Noguchi-Yachide, T., Sugita, K., Hashimoto, Y. & Ishikawa, M., 2010 Nov 15, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6661-6666 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
145 Citations (Scopus)