Kensaku Mizuno

President-appointed Extraordinary Professor

  • 13227 Citations
  • 60 h-Index
1978 …2020

Research output per year

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Research Output

  • 13227 Citations
  • 60 h-Index
  • 165 Article
  • 7 Review article
  • 2 Comment/debate
  • 1 Conference contribution
2020

Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP

Irie, K., Nagai, T. & Mizuno, K., 2020 Mar 6, In : Journal of Biological Chemistry. 295, 10, p. 3017-3028 12 p.

Research output: Contribution to journalArticle

The Rho-guanine nucleotide exchange factor Solo decelerates collective cell migration by modulating the Rho-ROCK pathway and keratin networks

Isozaki, Y., Sakai, K., Kohiro, K., Kagoshima, K., Iwamura, Y., Sato, H., Rindner, D., Fujiwara, S., Yamashita, K., Mizuno, K. & Ohashi, K., 2020 Mar, In : Molecular biology of the cell. 31, 8, p. 741-752 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Keratin-binding ability of the N-terminal Solo domain of Solo is critical for its function in cellular mechanotransduction

Fujiwara, S., Matsui, T. S., Ohashi, K., Mizuno, K. & Deguchi, S., 2019 May, In : Genes to Cells. 24, 5, p. 390-402 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Cullin-3–KCTD10-mediated CEP97 degradation promotes primary cilium formation

Nagai, T., Mukoyama, S., Kagiwada, H., Goshima, N. & Mizuno, K., 2018 Jan 1, In : Journal of cell science. 131, 24, jcs219527.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Glucose deprivation induces primary cilium formation through mTORC1 inactivation

Takahashi, K., Nagai, T., Chiba, S., Nakayama, K. & Mizuno, K., 2018 Jan 1, In : Journal of cell science. 131, 1, jcs.208769.

Research output: Contribution to journalArticle

10 Citations (Scopus)

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma

Wille, C., Eiseler, T., Langenberger, S. T., Richter, J., Mizuno, K., Radermacher, P., Knippschild, U., Huber-Lang, M., Seufferlein, T. & Paschke, S., 2018 Sep, In : Journal of Leukocyte Biology. 104, 3, p. 615-630 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells

Fujiwara, S., Matsui, T. S., Ohashi, K., Deguchi, S. & Mizuno, K., 2018 Apr, In : PloS one. 13, 4, e0195124.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Solo and keratin filaments regulate epithelial tubule morphology

Nishimura, R., Kato, K., Fujiwara, S., Ohashi, K. & Mizuno, K., 2018, In : Cell structure and function. 43, 1, p. 95-105 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1

Takahashi, K., Okabe, H., Kanno, S., Nagai, T. & Mizuno, K., 2017 Jan 22, In : Biochemical and biophysical research communications. 482, 4, p. 686-692 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation

Nagai, T. & Mizuno, K., 2017 Aug, In : PloS one. 12, 8, e0183030.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Localization of protein kinase NDR2 to peroxisomes and its role in ciliogenesis

Abe, S., Nagai, T., Masukawa, M., Okumoto, K., Homma, Y., Fujiki, Y. & Mizuno, K., 2017 Mar 10, In : Journal of Biological Chemistry. 292, 10, p. 4089-4098 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Requirement of gamma-carboxyglutamic acid modification and phosphatidylserine binding for the activation of Tyro3, Axl, and Mertk receptors by growth arrest-specific 6

Geng, K., Kumar, S., Kimani, S. G., Kholodovych, V., Kasikara, C., Mizuno, K., Sandiford, O., Rameshwar, P., Kotenko, S. V. & Birge, R. B., 2017 Nov 10, In : Frontiers in immunology. 8, NOV, 1521.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction

Ohashi, K., Fujiwara, S. & Mizuno, K., 2017, In : Journal of biochemistry. 161, 3, p. 245-254 10 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)
2016

Coordination of cellular dynamics contributes to tooth epithelium deformations

Morita, R., Kihira, M., Nakatsu, Y., Nomoto, Y., Ogawa, M., Ohashi, K., Mizuno, K., Tachikawa, T., Ishimoto, Y., Morishita, Y. & Tsuji, T., 2016 Sep, In : PloS one. 11, 9, e0161336.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Interplay between Solo and keratin filaments is crucial for mechanical forceinduced stress fiber reinforcement

Fujiwara, S., Ohashi, K., Mashiko, T., Kondo, H. & Mizuno, K., 2016 Mar 15, In : Molecular biology of the cell. 27, 6, p. 954-966 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Pharmacological inhibition of centrosome clustering by slingshot-mediated cofilin activation and actin cortex destabilization

Konotop, G., Bausch, E., Nagai, T., Turchinovich, A., Becker, N., Benner, A., Boutros, M., Mizuno, K., Krämer, A. & Raab, M. S., 2016 Nov 15, In : Cancer Research. 76, 22, p. 6690-6700 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Roles of cytoskeletons and cell adhesions in mechano-sensing

Fujiwara, S., Ohashi, K. & Mizuno, K., 2016 Jan 1, In : Seikagaku. 88, 4, p. 443-451 9 p.

Research output: Contribution to journalReview article

2015

Actin migration driven by directional assembly and disassembly of membrane-anchored actin filaments

Katsuno, H., Toriyama, M., Hosokawa, Y., Mizuno, K., Ikeda, K., Sakumura, Y. & Inagaki, N., 2015 Jan 1, In : Cell Reports. 12, 4, p. 648-660 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cep164, but not EB1, is critical for centriolar localization of TTBK2 and its function in ciliogenesis

Oda, T., Chiba, S., Nagai, T. & Mizuno, K., 2015 Jul 13, In : Cilia. SUPPLEMENT 1, P66.

Research output: Contribution to journalArticle

Rho guanine nucleotide exchange factors involved in cyclic-stretch-induced reorientation of vascular endothelial cells

Abiko, H., Fujiwara, S., Ohashi, K., Hiatari, R., Mashiko, T., Sakamoto, N., Sato, M. & Mizuno, K., 2015, In : Journal of cell science. 128, 9, p. 1683-1695 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2014

Activation of cytosolic Slingshot-1 phosphatase by gelsolin-generated soluble actin filaments

Takahashi, K., Kanno, S. I. & Mizuno, K., 2014 Nov 21, In : Biochemical and biophysical research communications. 454, 3, p. 471-477 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Citations (Scopus)

Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis

Oda, T., Chiba, S., Nagai, T. & Mizuno, K., 2014 Dec 1, In : Genes to Cells. 19, 12, p. 927-940 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Insulin receptor substrate-4 binds to slingshot-1 phosphatase and promotes cofilin dephosphorylation

Homma, Y., Kanno, S. I., Sasaki, K., Nishita, M., Yasui, A., Asano, T., Ohashi, K. & Mizuno, K., 2014 Sep 19, In : Journal of Biological Chemistry. 289, 38, p. 26302-26313 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Multifaceted roles of furry proteins in invertebrates and vertebrates

Nagai, T. & Mizuno, K., 2014 Mar 1, In : Journal of biochemistry. 155, 3, p. 137-146 10 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8

Amagai, Y., Itoh, T., Fukuda, M. & Mizuno, K., 2014 Dec 18, In : Journal of biochemistry. 158, 2, p. 139-153 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

CaMKIIβ-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis

Saito, A., Miyajima, K., Akatsuka, J., Kondo, H., Mashiko, T., Kiuchi, T., Ohashi, K. & Mizuno, K., 2013 Jul, In : Genes to Cells. 18, 7, p. 533-543 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Coactosin accelerates cell dynamism by promoting actin polymerization

Hou, X., Katahira, T., Ohashi, K., Mizuno, K., Sugiyama, S. & Nakamura, H., 2013 Jul 1, In : Developmental Biology. 379, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Erratum: β-Arrestin- dependent activation of the cofi lin pathway is required for the scavenging activity of the atypical chemokine receptor D6 (Science Signaling (2013) 6 (er5))

Borroni, E. M., Cancellieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., Arenzana-Seisdedos, F., Mizuno, K., Mantovani, A., Bonecchi, R. & Locati, M., 2013 Aug 13, In : Science Signaling. 6, 288, er5.

Research output: Contribution to journalComment/debate

F-and G-actin homeostasis regulates mechanosensitive actin nucleation by formins

Higashida, C., Kiuchi, T., Akiba, Y., Mizuno, H., Maruoka, M., Narumiya, S., Mizuno, K. & Watanabe, N., 2013 Apr, In : Nature cell biology. 15, 4, p. 395-405 11 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase

Nagai, T., Ikeda, M., Chiba, S., Kanno, S. I. & Mizuno, K., 2013, In : Journal of cell science. 126, 19, p. 4369-4380 12 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
66 Citations (Scopus)

P63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells

Hayashi, A., Hiatari, R., Tsuji, T., Ohashi, K. & Mizuno, K., 2013 Mar 18, In : FEBS Letters. 587, 6, p. 698-705 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

Mizuno, K., 2013 Feb 1, In : Cellular Signalling. 25, 2, p. 457-469 13 p.

Research output: Contribution to journalReview article

215 Citations (Scopus)

β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6

Borroni, E. M., Cancellieri, C., Vacchini, A., Benureau, Y., Lagane, B., Bachelerie, F., Arenzana-Seisdedos, F., Mizuno, K., Mantovani, A., Bonecchi, R. & Locati, M., 2013 Apr 30, In : Science Signaling. 6, 273, p. ra30

Research output: Contribution to journalArticle

45 Citations (Scopus)
2012

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S. O., Dong, Y., Tokuda, M., Morikawa, T., Hikasa, H., Eggenschwiler, J., Yabuta, N., Nojima, H., Nakagawa, K., Hata, Y., Nishina, H., Mimori, K., Mori, M. & 5 others, Sasaki, T., Mak, T. W., Nakano, T., Itami, S. & Suzuki, A., 2012 Dec 3, In : Journal of Clinical Investigation. 122, 12, p. 4505-4518 14 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Cytochalasin D acts as an inhibitor of the actin-cofilin interaction

Shoji, K., Ohashi, K., Sampei, K., Oikawa, M. & Mizuno, K., 2012 Jul 20, In : Biochemical and biophysical research communications. 424, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Erratum: Global phosphorylation analysis of ß-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)

Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villén, J., Haas, W., Kovacs, J. J., Shukla, A. K., Hara, M. R., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma'ayan, A., Gygi, S. P. & Lefkowitz, R. J., 2012 Aug 14, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 33, 1 p.

Research output: Contribution to journalComment/debate

Furry protein promotes Aurora A-mediated polo-like kinase 1 activation

Ikeda, M., Chiba, S., Ohashi, K. & Mizuno, K., 2012 Aug 10, In : Journal of Biological Chemistry. 287, 33, p. 27670-27681 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release

Sakuma, M., Shirai, Y., Yoshino, K. I., Kuramasu, M., Nakamura, T., Yanagita, T., Mizuno, K., Hide, I., Nakata, Y. & Saito, N., 2012 Sep 15, In : Molecular biology of the cell. 23, 18, p. 3707-3721 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments

Ohashi, K., Kiuchi, T., Shoji, K., Sampei, K. & Mizuno, K., 2012 Jan, In : BioTechniques. 52, 1, p. 45-50 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2011

CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment

Itoh, G., Kanno, S. I., Uchida, K. S. K., Chiba, S., Sugino, S., Watanabe, K., Mizuno, K., Yasui, A., Hirota, T. & Tanaka, K., 2011 Jan 5, In : EMBO Journal. 30, 1, p. 130-144 15 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation

Freeman, S. A., Lei, V., Dang-Lawson, M., Mizuno, K., Roskelley, C. D. & Gold, M. R., 2011 Dec 1, In : Journal of Immunology. 187, 11, p. 5887-5900 14 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization

Ohashi, K., Fujiwara, S., Watanabe, T., Kondo, H., Kiuchi, T., Sato, M. & Mizuno, K., 2011 Oct 21, In : Journal of Biological Chemistry. 286, 42, p. 36340-36351 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
55 Citations (Scopus)

Protein kinase D regulates cofilin activity through p21-activated kinase 4

Spratley, S. J., Bastea, L. I., Döppler, H., Mizuno, K. & Storz, P., 2011 Oct 30, In : Journal of Biological Chemistry. 286, 39, p. 34254-34261 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2010

Actin-depolymerizing factor cofilin-1 is necessary in maintaining mature podocyte architecture

Garg, P., Verma, R., Cook, L., Soofi, A., Venkatareddy, M., George, B., Mizuno, K., Gurniak, C., Witke, W. & Holzman, L. B., 2010 Jul 16, In : Journal of Biological Chemistry. 285, 29, p. 22676-22688 13 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villén, J., Haas, W., Kovacs, J. J., Shukla, A. K., Hara, M. R., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma'ayan, A., Gygi, S. P. & Lefkowitz, R. J., 2010 Aug 24, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15299-15304 6 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)

Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells

Tsuji, T., Ohta, Y., Kanno, Y., Hirose, K., Ohashi, K. & Mizuno, K., 2010 Oct 15, In : Molecular biology of the cell. 21, 20, p. 3590-3600 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

LIM-kinase is critical for the mesenchymal-to-amoeboid cell morphological transition in 3D matrices

Mishima, T., Naotsuka, M., Horita, Y., Sato, M., Ohashi, K. & Mizuno, K., 2010 Feb 19, In : Biochemical and biophysical research communications. 392, 4, p. 577-581 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)