Hisanori Horiuchi

Professor

  • 5366 Citations
  • 37 h-Index
1988 …2020

Research output per year

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Research Output

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Article
2020

A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus

Shirakawa, R., Goto-Ito, S., Goto, K., Wakayama, S., Kubo, H., Sakata, N., Trinh, D. A., Yamagata, A., Sato, Y., Masumoto, H., Cheng, J., Fujimoto, T., Fukai, S. & Horiuchi, H., 2020 Apr 15, In : EMBO Journal. 39, 8, e104120.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Disappearance of angiodysplasia following transcatheter aortic valve implantation in a patient with heyde’s syndrome: A case report and review of the literature

Tsuchiya, S., Matsumoto, Y., Doman, T., Fujiya, T., Sugisawa, J., Suda, A., Sato, K., Ikeda, S., Shindo, T., Kikuchi, Y., Hao, K., Takahashi, J., Hatta, W., Koike, T., Masamune, A., Saiki, Y., Horiuchi, H. & Shimokawa, H., 2020, In : Journal of atherosclerosis and thrombosis. 27, 3, p. 271-277 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation

Iida, T., Hirayama, D., Minami, N., Matsuura, M., Wagatsuma, K., Kawakami, K., Nagaishi, K., Nojima, M., Ikeuchi, H., Hirota, S., Shirakawa, R., Horiuchi, H. & Nakase, H., 2020, In : CMGH. 9, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

Acquired von Willebrand syndrome in patients treated with veno-arterial extracorporeal membrane oxygenation

Tamura, T., Horiuchi, H., Obayashi, Y., Fuki, M., Imanaka, M., Kuroda, M., Nishimura, S., Amano, M., Sakamoto, J., Tamaki, Y., Enomoto, S., Miyake, M., Kondo, H., Izumi, C. & Nakagawa, Y., 2019 Oct 1, In : Cardiovascular Intervention and Therapeutics. 34, 4, p. 358-363 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis

Uegaki, M., Kita, Y., Shirakawa, R., Teramoto, Y., Kamiyama, Y., Saito, R., Yoshikawa, T., Sakamoto, H., Goto, T., Akamatsu, S., Yamasaki, T., Inoue, T., Suzuki, A., Horiuchi, H., Ogawa, O. & Kobayashi, T., 2019 Dec 1, In : Carcinogenesis. 40, 12, p. 1535-1544 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Inhibitor of Growth 4 (ING4) is a positive regulator of rRNA synthesis

Trinh, D. A., Shirakawa, R., Kimura, T., Sakata, N., Goto, K. & Horiuchi, H., 2019 Dec 1, In : Scientific reports. 9, 1, 17235.

Research output: Contribution to journalArticle

Open Access

Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression

Gao, P., Liu, S., Yoshida, R., Shi, C. Y., Yoshimachi, S., Sakata, N., Goto, K., Kimura, T., Shirakawa, R., Nakayama, H., Sakata, J., Kawashiri, S., Kato, K., Wang, X. Y. & Horiuchi, H., 2019 Aug 1, In : Journal of dental research. 98, 9, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018
9 Citations (Scopus)

C2 domains of Munc13-4 are crucial for Ca2+-dependent degranulation and cytotoxicity in NK cells

Bin, N. R., Ma, K., Tien, C. W., Wang, S., Zhu, D., Park, S., Turlova, E., Sugita, K., Shirakawa, R., Van Der Sluijs, P., Horiuchi, H., Sun, H. S., Monnier, P. P., Gaisano, H. Y. & Sugita, S., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 700-713 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis

Shibata, H., Yasumi, T., Shimodera, S., Hiejima, E., Izawa, K., Kawai, T., Shirakawa, R., Wada, T., Nishikomori, R., Horiuchi, H., Ohara, O., Ishii, E. & Heike, T., 2018 May 3, In : Blood. 131, 18, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Impact of Baseline Thrombocytopenia on Bleeding and Mortality After Percutaneous Coronary Intervention

Ito, S., Watanabe, H., Morimoto, T., Yoshikawa, Y., Shiomi, H., Shizuta, S., Ono, K., Yamaji, K., Soga, Y., Hyodo, M., Shirai, S., Ando, K., Horiuchi, H. & Kimura, T., 2018 Jun 1, In : American Journal of Cardiology. 121, 11, p. 1304-1314 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2017

A CD57+ CTL Degranulation Assay Effectively Identifies Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients

Hori, M., Yasumi, T., Shimodera, S., Shibata, H., Hiejima, E., Oda, H., Izawa, K., Kawai, T., Ishimura, M., Nakano, N., Shirakawa, R., Nishikomori, R., Takada, H., Morita, S., Horiuchi, H., Ohara, O., Ishii, E. & Heike, T., 2017 Jan 1, In : Journal of Clinical Immunology. 37, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity

Horiuchi, T., Sakata, N., Narumi, Y., Kimura, T., Hayashi, T., Nagano, K., Liu, K., Nishibori, M., Tsukita, S., Yamada, T., Katagiri, H., Shirakawa, R. & Horiuchi, H., 2017 May 19, In : Journal of Biological Chemistry. 292, 20, p. 8436-8446 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2016
4 Citations (Scopus)

Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Sakatsume, K., Akiyama, M., Saito, K., Kawamoto, S., Horiuchi, H. & Saiki, Y., 2016 Sep 1, In : Journal of Artificial Organs. 19, 3, p. 289-292 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Platelet aggregability in patients with interstitial pneumonias

Handa, T., Watanabe, K., Tanizawa, K., Oga, T., Aihara, K., Ikezoe, K., Sokai, A., Nakatsuka, Y., Hirai, T., Nagai, S., Chin, K., Horiuchi, H. & Mishima, M., 2016 Aug 1, In : Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 33, 2, p. 143-150 8 p.

Research output: Contribution to journalArticle

Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP

Shishikura, K., Horiuchi, T., Sakata, N., Trinh, D. A., Shirakawa, R., Kimura, T., Asada, Y. & Horiuchi, H., 2016 Jan 1, In : British Journal of Pharmacology. 173, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension

Yaoita, N., Satoh, K., Satoh, T., Sugimura, K., Tatebe, S., Yamamoto, S., Aoki, T., Miura, M., Miyata, S., Kawamura, T., Horiuchi, H., Fukumoto, Y. & Shimokawa, H., 2016 Jun 1, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 6, p. 1293-1301 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

Ral GTPases: Crucial mediators of exocytosis and tumourigenesis

Shirakawa, R. & Horiuchi, H., 2015 May 1, In : Journal of biochemistry. 157, 5, p. 285-299 15 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Unexpectedly high prevalence of acquired von Willebrand syndrome in patients with severe aortic stenosis as evaluated with a novel large multimer index

Tamura, T., Horiuchi, H., Imai, M., Tada, T., Shiomi, H., Kuroda, M., Nishimura, S., Takahashi, Y., Yoshikawa, Y., Tsujimura, A., Amano, M., Hayama, Y., Imamura, S., Onishi, N., Tamaki, Y., Enomoto, S., Miyake, M., Kondo, H., Kaitani, K., Izumi, C. & 2 others, Kimura, T. & Nakagawa, Y., 2015 Nov 2, In : Journal of atherosclerosis and thrombosis. 22, 11, p. 1115-1123 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2014

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., Li, C., Yang, Z., MacKintosh, C., Wang, H. Y. & Chen, S., 2014 Aug, In : Cellular Signalling. 26, 8, p. 1636-1648 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension

Yaoita, N., Shirakawa, R., Fukumoto, Y., Sugimura, K., Miyata, S., Miura, Y., Nochioka, K., Miura, M., Tatebe, S., Aoki, T., Yamamoto, S., Satoh, K., Kimura, T., Shimokawa, H. & Horiuchi, H., 2014 Nov 1, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 11, p. 2486-2494 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production

Kimura, T., Shirakawa, R., Yaoita, N., Hayashi, T., Nagano, K. & Horiuchi, H., 2014 Oct 16, In : FEBS Letters. 588, 20, p. 3673-3676 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

Saito, R., Shirakawa, R., Nishiyama, H., Kobayashi, T., Kawato, M., Kanno, T., Nishizawa, K., Matsui, Y., Ohbayashi, T., Horiguchi, M., Nakamura, T., Ikeda, T., Yamane, K., Nakayama, E., Nakamura, E., Toda, Y., Kimura, T., Kita, T., Ogawa, O. & Horiuchi, H., 2013 Feb 14, In : Oncogene. 32, 7, p. 894-902 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2012

A complete rab screening reveals novel insights in Weibel-Palade body exocytosis

Zografou, S., Basagiannis, D., Papafotika, A., Shirakawa, R., Horiuchi, H., Auerbach, D., Fukuda, M. & Christoforidis, S., 2012, In : Journal of cell science. 125, 20, p. 4780-4790 11 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Effects of ppis and an H2 blocker on the antiplatelet function of clopidogrel in Japanese patients under dual antiplatelet therapy

Yamane, K., Kato, Y., Tazaki, J., Tada, T., Makiyama, T., Imai, M., Jinnai, T., Ikeda, T., Shirakawa, R., Kimura, T. & Horiuchi, H., 2012 Jul 11, In : Journal of atherosclerosis and thrombosis. 19, 6, p. 559-569 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Impact of platelet reactivity on long-term clinical outcomes and bleeding events in Japanese patients receiving antiplatelet therapy with aspirin

Yamane, K., Ikeda, T., Taniguchi, R., Watanabe, S., Kawato, M., Kondo, H., Shirakawa, R., Higashi, T., Toma, M., Tabuchi, A., Tamura, T., Takahashi, K., Watanabe, H., Yoshikawa, Y., Kita, T., Kimura, T. & Horiuchi, H., 2012, In : Journal of atherosclerosis and thrombosis. 19, 12, p. 1142-1153 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

Boswell, K. L., James, D. J., Esquibel, J. M., Bruinsma, S., Shirakawa, R., Horiuchi, H. & Martin, T. F. J., 2012 Apr, In : Journal of Cell Biology. 197, 2, p. 301-312 12 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Prediction of clopidogrel low responders by a rapid CYP2C19 activity test

Tazaki, J., Jinnai, T., Tada, T., Kato, Y., Makiyama, T., Ikeda, T., Yamane, K., Naruse, Y., Takahashi, K., Watanabe, H., Kimura, T. & Horiuchi, H., 2012 Mar 5, In : Journal of atherosclerosis and thrombosis. 19, 2, p. 186-193 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation

Shirai, Y., Morioka, S., Sakuma, M., Yoshino, K. I., Otsujia, C., Sakai, N., Kashiwagi, K., Chida, K., Shirakawa, R., Horiuchi, H., Nishigori, C., Ueyama, T. & Saito, N., 2011 Apr 15, In : Molecular biology of the cell. 22, 8, p. 1340-1352 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Drug interaction between clopidogrel and proton pump inhibitors

Yamane, K. & Horiuchi, H., 2011 Nov 1, In : Japanese Journal of Clinical Pharmacology and Therapeutics. 42, 6, p. 383-388 6 p.

Research output: Contribution to journalArticle

Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein

Murata, Y., Yasumi, T., Shirakawa, R., Izawa, K., Sakai, H., Abe, J., Tanaka, N., Kawai, T., Oshima, K., Saito, M., Nishikomori, R., Ohara, O., Ishii, E., Nakahata, T., Horiuchi, H. & Heike, T., 2011 Aug 4, In : Blood. 118, 5, p. 1225-1230 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2010

Characterization of the antiplatelet effect of aspirin at enrollment and after 2-year follow-up in a real clinical setting in Japan

Ikeda, T., Taniguchi, R., Watanabe, S., Kawato, M., Kondo, H., Shirakawa, R., Yamane, K., Toma, M., Tamura, T., Takahashi, K., Watanabe, H., Yoshikawa, Y., Tabuchi, A., Kita, T., Kimura, T. & Horiuchi, H., 2010, In : Circulation Journal. 74, 6, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase

Higashi, T., Ikeda, T., Murakami, T., Shirakawa, R., Kawato, M., Okawa, K., Furuse, M., Kimura, T., Kita, T. & Horiuchi, H., 2010 May 21, In : Journal of Biological Chemistry. 285, 21, p. 16231-16238 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Insulin-like growth factor axis (insulin-like growth factor-I/insulin-like growth factor-binding protein-3) as a prognostic predictor of heart failure: Association with adiponectin

Watanabe, S., Tamura, T., Ono, K., Horiuchi, H., Kimura, T., Kita, T. & Furukawa, Y., 2010 Nov, In : European Journal of Heart Failure. 12, 11, p. 1214-1222 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2009

Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention

Hoshino, K., Horiuchi, H., Tada, T., Tazaki, J., Nishi, E., Kawato, M., Ikeda, T., Yamamoto, H., Akao, M., Furukawa, Y., Shizuta, S., Toma, M., Tamura, T., Saito, N., Doi, T., Ozasa, N., Jinnai, T., Takahashi, K., Watanabe, H., Yoshikawa, Y. & 5 others, Nishimoto, N., Ouchi, C., Morimoto, T., Kita, T. & Kimura, T., 2009 Feb 10, In : Circulation Journal. 73, 2, p. 336-342 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

Wood, S. M., Meeths, M., Chiang, S. C. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C., Horiuchi, H., Rosthøj, S., Rutynowska, O., Winiarski, J., Stow, J. L., Nordenskjöld, M., Henter, J. I., Ljunggren, H. G. & Bryceson, Y. T., 2009 Nov 5, In : Blood. 114, 19, p. 4117-4127 11 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Effects of obstructive sleep apnea with intermittent hypoxia on platelet aggregability.

Oga, T., Chin, K., Tabuchi, A., Kawato, M., Morimoto, T., Takahashi, K., Handa, T., Takahashi, K., Taniguchi, R., Kondo, H., Mishima, M., Kita, T. & Horiuchi, H., 2009, In : Journal of atherosclerosis and thrombosis. 16, 6, p. 862-869 8 p.

Research output: Contribution to journalArticle

Open Access
51 Citations (Scopus)

Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan

Jinnai, T., Horiuchi, H., Makiyama, T., Tazaki, J., Tada, T., Akao, M., Ono, K., Hoshino, K., Naruse, Y., Takahashi, K., Watanabe, H., Kita, T. & Kimura, T., 2009 Aug 1, In : Circulation Journal. 73, 8, p. 1498-1503 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases

Shirakawa, R., Fukai, S., Kawato, M., Higashi, T., Kondo, H., Ikeda, T., Nakayama, E., Okawa, K., Nureki, O., Kimura, T., Kita, T. & Horiuchi, H., 2009 Aug 7, In : Journal of Biological Chemistry. 284, 32, p. 21580-21588 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2008

Action of aspirin on whole blood-aggregation evaluated by the screen filtration pressure method

Tabuchi, A., Taniguchi, R., Takahashi, K., Kondo, H., Kawato, M., Morimoto, T., Kimura, T., Kita, T. & Horiuchi, H., 2008, In : Circulation Journal. 72, 3, p. 420-426 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets

Higashi, T., Ikeda, T., Shirakawa, R., Kondo, H., Kawato, M., Horiguchi, M., Okuda, T., Okawa, K., Fukai, S., Nureki, O., Kita, T. & Horiuchi, H., 2008 Mar 28, In : Journal of Biological Chemistry. 283, 13, p. 8746-8755 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Evaluation of the antiplatelet effects of cilostazol, a phosphodiesterase 3 inhibitor, by VASP phosphorylation and platelet aggregation

Yamamoto, H., Takahashi, K., Watanabe, H., Yoshikawa, Y., Shirakawa, R., Higashi, T., Kawato, M., Ikeda, T., Tabuchi, A., Morimoto, T., Kita, T. & Horiuchi, H., 2008, In : Circulation Journal. 72, 11, p. 1844-1851 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway

Kawato, M., Shirakawa, R., Kondo, H., Higashi, T., Ikeda, T., Okawa, K., Fukai, S., Nureki, O., Kita, T. & Horiuchi, H., 2008 Jan 4, In : Journal of Biological Chemistry. 283, 1, p. 166-174 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Sustained release of prostaglandin E1 potentiates the impaired therapeutic angiogenesis by basic fibroblast growth factor in diabetic murine hindlimb ischemia

Huang, Y., Marui, A., Sakaguchi, H., Esaki, J., Arai, Y., Hirose, K., Bir, S. C., Horiuchi, H., Maruyama, T., Ikeda, T., Tabata, Y. & Komeda, M., 2008, In : Circulation Journal. 72, 10, p. 1693-1699 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2007

Asymmetric Coiled-Coil Structure with Guanine Nucleotide Exchange Activity

Sato, Y., Shirakawa, R., Horiuchi, H., Dohmae, N., Fukai, S. & Nureki, O., 2007 Feb 1, In : Structure. 15, 2, p. 245-252 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Crystal structure of human DAAM1 formin homology 2 domain

Yamashita, M., Higashi, T., Suetsugu, S., Sato, Y., Ikeda, T., Shirakawa, R., Kita, T., Takenawa, T., Horiuchi, H., Fukai, S. & Nureki, O., 2007 Nov, In : Genes to Cells. 12, 11, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Nationwide survey of hemophagocytic lymphohistiocytosis in Japan

Ishii, E., Ohga, S., Imashuku, S., Yasukawa, M., Tsuda, H., Miura, I., Yamamoto, K., Horiuchi, H., Takada, K., Ohshima, K., Nakamura, S., Kinukawa, N., Oshimi, K. & Kawa, K., 2007 Jul, In : International journal of hematology. 86, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

240 Citations (Scopus)

Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis

Nagafuji, K., Nonami, A., Kumano, T., Kikushige, Y., Yoshimoto, G., Takenaka, K., Shimoda, K., Ohga, S., Yasukawa, M., Horiuchi, H., Ishii, E. & Harada, M., 2007 Jul, In : Haematologica. 92, 7, p. 978-981 4 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Recurrent hemophagocytic lymphohistiocytosis accompanied by Kikuchi's disease

Lin, Y. W., Horiuchi, H., Ueda, I. & Nambu, M., 2007 Dec 1, In : Leukemia and Lymphoma. 48, 12, p. 2447-2451 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)