• 29 Citations
  • 3 h-Index
20152020

Research output per year

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Research Output

  • 29 Citations
  • 3 h-Index
  • 9 Article
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Article
2020

CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity

Gutiérrez Rico, E. M., Kikuchi, A., Saito, T., Kumondai, M., Hishinuma, E., Kaneko, A., Chan, C. W., Gitaka, J., Nakayoshi, T., Oda, A., Saito, S., Hirasawa, N. & Hiratsuka, M., 2020 Feb, In : Drug metabolism and pharmacokinetics. 35, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population

Fukunaga, K., Hishinuma, E., Hiratsuka, M., Kato, K., Okusaka, T., Saito, T., Ikeda, M., Yoshida, T., Zembutsu, H., Iwata, N. & Mushiroda, T., 2020, (Accepted/In press) In : Journal of Human Genetics.

Research output: Contribution to journalArticle

Heterologous expression of high-activity cytochrome P450 in mammalian cells

Kumondai, M., Hishinuma, E., Gutiérrez Rico, E. M., Ito, A., Nakanishi, Y., Saigusa, D., Hirasawa, N. & Hiratsuka, M., 2020 Dec 1, In : Scientific reports. 10, 1, 14193.

Research output: Contribution to journalArticle

Open Access
2019
2 Citations (Scopus)
2018

Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)

Kumondai, M., Ito, A., Hishinuma, E., Kikuchi, A., Saito, T., Takahashi, M., Tsukada, C., Saito, S., Yasuda, J., Nagasaki, M., Minegishi, N., Yamamoto, M., Kaneko, A., Teramoto, I., Kimura, M., Hirasawa, N. & Hiratsuka, M., 2018 Dec, In : Drug metabolism and pharmacokinetics. 33, 6, p. 258-263 6 p.

Research output: Contribution to journalArticle

Functional characterization of 21 allelic variants of dihydropyrimidine dehydrogenase identified in 1070 Japanese individuals

Hishinuma, E., Narita, Y., Saito, S., Maekawa, M., Akai, F., Nakanishi, Y., Yasuda, J., Nagasaki, M., Yamamoto, M., Yamaguchi, H., Mano, N., Hirasawa, N. & Hiratsuka, M., 2018 Aug, In : Drug Metabolism and Disposition. 46, 8, p. 1083-1090 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation

Watanabe, T., Saito, T., Rico, E. M. G., Hishinuma, E., Kumondai, M., Maekawa, M., Oda, A., Saigusa, D., Saito, S., Yasuda, J., Nagasaki, M., Minegishi, N., Yamamoto, M., Yamaguchi, H., Mano, N., Hirasawa, N. & Hiratsuka, M., 2018 Oct, In : Biochemical Pharmacology. 156, p. 420-430 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Functional characterization of 21 allelic variants of dihydropyrimidinase

Hishinuma, E., Akai, F., Narita, Y., Maekawa, M., Yamaguchi, H., Mano, N., Oda, A., Hirasawa, N. & Hiratsuka, M., 2017 Nov 1, In : Biochemical Pharmacology. 143, p. 118-128 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Genetic polymorphisms of dihydropyrimidinase in a Japanese patient with capecitabine-induced toxicity

Hiratsuka, M., Yamashita, H., Akai, F., Hosono, H., Hishinuma, E., Hirasawa, N. & Mori, T., 2015 Apr 27, In : PloS one. 10, 4, e0124818.

Research output: Contribution to journalArticle

12 Citations (Scopus)